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 防衛医科大学校
 分子生体制御学講座
 Department of Integrative Physiology and Bio-Nano Medicine,
 National Defense Medical College

 防衛医大・分子生体制御学講座の公式ウェブサイトです。
 Official website for Dept. Integrative Physiol. Bio-Nano Med., Natl. Defense Med. Col.


















講座の業績 　　

・各スタッフごとの業績はこちらをご参照下さい

＜2022年＞
  1. Y. Shirai, A. Nakayama, Y. Kawamura, Y. Toyoda, M. Nakatochi, S. Shimizu, N. Shinomiya, Y. Okada, H. Matsuo, Coffee consumption reduces gout risk independently of serum uric acid levels: Mendelian randomization analyses across ancestry populations. ACR Open Rheumatol. (2022).
    研究の紹介　　 オープンアクセス

  2. Y. Toyoda, A. Nakayama, M. Nakatochi, Y. Kawamura, H. Nakaoka, K. Yamamoto, S. Shimizu, H. Ooyama, K. Ooyama, T. Shimizu, M. Nagase, Y. Hidaka, K. Ichida, I. Inoue, N. Shinomiya, H. Matsuo, C. Japan Gout Genomics, Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations. Mol Genet Metab. (2022).
    オープンアクセス

  3. S. J. Chang, Y. Toyoda, Y. Kawamura, T. Nakamura, M. Nakatochi, A. Nakayama, W. T. Liao, S. Shimizu, T. Takada, K. Takeuchi, K. Wakai, Y. Shi, N. Shinomiya, C. J. Chen, C. Li, Y. Okada, K. Ichida, H. Matsuo, C. for Japan Gout Genomics, A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility. Hum Cell. 35(2):767-770 (2022).
    オープンアクセス

  4. C. Domenighetti, PE. Sugier, AAK. Sreelatha, C. Schulte, S. Grover, O. Mohamed, B. Portugal, P. May, DR. Bobbili, M. Radivojkov-Blagojevic, P. Lichtner, AB. Singleton, DG. Hernandez, C. Edsall, GD. Mellick, A. Zimprich, W. Pirker, E. Rogaeva, AE. Lang, S. Koks, P. Taba, S. Lesage, A. Brice, JC. Corvol, MC. Chartier-Harlin, E. Mutez, K. Brockmann, AB. Deutschländer, GM. Hadjigeorgiou, E. Dardiotis, L. Stefanis, AM. Simits, EM. Valente, S. Petrucci, S. Duga, L. Straniero, A. Zecchinelli, G. Pezzoli, L. Brighina, C. Ferrarese, G. Annesi, A. Quattrone, M. Gagliardi, H. Matsuo, Y. Kawamura, N. Hattori, K. Nishioka, SJ. Chung, YJ. Kim, P. Kolber, BP. van de Warrenburg, BR. Bloem, J. Aasly, M. Toft, L. Pihlstrøm, LC Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, M. Ezquerra, P. Pastor, M. Diez-Fairen, K. Wirdefeldt, NL. Pedersen, C. Ran, AC. Belin, A. Puschmann, C. Hellberg, CE. Clarke, KE. Morrison, M. Tan, D. Krainc, LF. Burbulla, MJ. Farrer, R. Krüger, T. Gasser, M. Sharma, A. Elbaz; Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium. Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease. J Parkinsons Dis. 12(1):267-282, (2022).

  5. C. Domenighetti, P. E. Sugier, A. Ashok Kumar Sreelatha, C. Schulte, S. Grover, O. Mohamed, B. Portugal, P. May, D. R. Bobbili, M. Radivojkov-Blagojevic, P. Lichtner, A. B. Singleton, D. G. Hernandez, C. Edsall, G. D. Mellick, A. Zimprich, W. Pirker, E. Rogaeva, A. E. Lang, S. Koks, P. Taba, S. Lesage, A. Brice, J. C. Corvol, M. C. Chartier-Harlin, E. Mutez, K. Brockmann, A. B. Deutschlander, G. M. Hadjigeorgiou, E. Dardiotis, L. Stefanis, A. M. Simitsi, E. M. Valente, S. Petrucci, S. Duga, L. Straniero, A. Zecchinelli, G. Pezzoli, L. Brighina, C. Ferrarese, G. Annesi, A. Quattrone, M. Gagliardi, H. Matsuo, Y. Kawamura, N. Hattori, K. Nishioka, S. J. Chung, Y. J. Kim, P. Kolber, B. P. C. van de Warrenburg, B. R. Bloem, J. Aasly, M. Toft, L. Pihlstrom, L. Correia Guedes, J. J. Ferreira, S. Bardien, J. Carr, E. Tolosa, M. Ezquerra, P. Pastor, M. Diez-Fairen, K. Wirdefeldt, N. L. Pedersen, C. Ran, A. C. Belin, A. Puschmann, C. Hellberg, C. E. Clarke, K. E. Morrison, M. Tan, D. Krainc, L. F. Burbulla, M. J. Farrer, R. Kruger, T. Gasser, M. Sharma, A. Elbaz, G. Comprehensive Unbiased Risk Factor Assessment for, C. Environment in Parkinson's Disease, Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. Mov Disord, (2022).

＜2021年＞
  1. M. Ogura, Y. Toyoda, M. Sakiyama, Y. Kawamura, A. Nakayama, Y. Yamanashi, T. Takada, S. Shimizu, T. Higashino, M. Nakajima, M. Naito, A. Hishida, S. Kawai, R. Okada, M. Sasaki, M. Ayaori, H. Suzuki, K. Takata, K. Ikewaki, M. Harada-Shiba, N. Shinomiya, H. Matsuo. Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach. Hum Cell. 34(6):1727-1733, (2021).
    オープンアクセス

  2. Y. Kawamura, A. Nakayama, S. Shimizu, Y. Toyoda, Y. Nishida, A. Hishida, S. Katsuura-Kamano, K. Shibuya, T. Tamura, M. Kawaguchi, S. Suzuki, S. Iwasawa, H. Nakashima, R. Ibusuki, H. Uemura, M. Hara, K. Takeuchi, T. Takada, M. Tsunoda, K. Arisawa, T. Takezaki, K. Tanaka, K. Ichida, K. Wakai, N. Shinomiya, H. Matsuo. A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals. Biomedicines.; 9(8):1012, (2021).
    オープンアクセス

  3. A. Nakayama, Y. Kawamura, Y. Toyoda, S. Shimizu, M. Kawaguchi, Y. Aoki, K. Takeuchi, R. Okada, Y. Kubo, T. Imakiire, S. Iwasawa, H. Nakashima, M. Tsunoda, K. Ito, H. Kumagai, T. Takada, K. Ichida, N. Shinomiya, H. Matsuo. Genetic-epidemiological analysis of hypouricemia from 4,993 Japanese on nonfunctional variants of URAT1/SLC22A12 gene. Rheumatology (Oxford). (2021).
    オープンアクセス

  4. M. Sakiyama, H. Matsuo, Y. Toyoda, Y. Yonekura, T. Ishikawa, A. Nakayama, T. Higashino, Y. Kawamura, N. Fujimoto, N. Shinomiya, T. Satoh. Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity. Hum Cell. 34(4):1082-1086, (2021).
    オープンアクセス

  5. Y. Toyoda, Y. Kawamura, A. Nakayama, H. Nakaoka, T. Higashino, S. Shimizu, H. Ooyama, K. Morimoto, N. Uchida, R. Shigesawa, K. Takeuchi, I. Inoue, K. Ichida, H. Suzuki, N. Shinomiya, T. Takada, H. Matsuo. Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12. Rheumatology (Oxford). 2021.
    オープンアクセス

  6. M. Nakatochi, Y. Toyoda, M. Kanai, A. Nakayama, Y. Kawamura, A. Hishida, H. Mikami, K. Matsuo, T. Takezaki, Y. Momozawa, Project TBJ, Y. Kamatani, S. Ichihara, N. Shinomiya, M. Yokota, K. Wakai, Y. Okada, H. Matsuo; Japan Uric Acid Genomics Consortium (Japan Urate). An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate. Rheumatology (Oxford). 2021.
    オープンアクセス

  7. M Kawaguchi, A Nakayama, Y Aoyagi, T Nakamura, S Shimizu, Y Kawamura, M Takao, T Tamura, A Hishida, M Nagayoshi, M Nagase, K Ooyama, H Ooyama, N Shinomiya, H Matsuo. Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. Hum Cell. (2021).
    オープンアクセス

＜2020年＞
  1. Y. Toyoda, T. Takada, H. Miyata, H. Matsuo, H. Kassai, K. Nakao, M. Nakatochi, Y. Kawamura, S. Shimizu, N. Shinomiya, K. Ichida, M. Hosoyamada, A. Aiba, H. Suzuki. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Proc Natl Acad Sci U S A.;117(31):18175-18177, (2020)

  2. Y. Kawamura, Y. Toyoda, T. Ohnishi, R. Hisatomi, T. Higashino, A. Nakayama, S. Shimizu, M. Yanagi, I. Kamimaki, R. Fujimaru, H. Suzuki, N. Shinomiya, T. Takada, H. Matsuo. Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families. Rheumatology (Oxford), 59(12):3988-3990 (2020).
    オープンアクセス

  3. A. Nakayama, M. Nakatochi, Y. Kawamura, K. Yamamoto, H. Nakaoka, S. Shimizu, T. Higashino, T. Koyama, A. Hishida, K. Kuriki, M. Watanabe, T. Shimizu, K. Ooyama, H. Ooyama, M. Nagase, Y. Hidaka, D. Matsui, T. Tamura, T. Nishiyama, C. Shimanoe, S. Katsuura-Kamano, N. Takashima, Y. Shirai, M. Kawaguchi, M. Takao, R. Sugiyama, Y. Takada, T. Nakamura, H. Nakashima, M. Tsunoda, I. Danjoh, A. Hozawa, K. Hosomichi, Y. Toyoda, Y. Kubota, T. Takada, H. Suzuki, Blanka Stiburkova, T. J. Major, T. R. Merriman, N. Kuriyama, H. Mikami, T. Takezaki, K. Matsuo, S. Suzuki, T. Hosoya, Y. Kamatani, M. Kubo, K. Ichida, K. Wakai, I. Inoue, Y. Okada, N. Shinomiya, H. Matsuo on behalf of Japan Gout Genomics Consortium (Japan Gout). Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. Ann. Rheum. Dis. (2020) (epub ahead of print on Apr. 1, 2020).
    プレスリリース　　 オープンアクセス

  4. A. Akashi, A. Nakayama, Y. Kamatani, T. Higashino, S. Shimizu, Y. Kawamura, M. Imoto, M. Naito, A. Hishida, M. Kawaguchi, M. Takao, M. Matsuo, T. Takada, K. Ichida, H. Ooyama, N. Shinomiya, H. Matsuo, A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. Hum Cell 33, 303-307 (2020).
    オープンアクセス

  5. T. Higashino, K. Morimoto, H. Nakaoka, Y. Toyoda, Y. Kawamura, S. Shimizu, T. Nakamura, K. Hosomichi, A. Nakayama, K. Ooyama, H. Ooyama, T. Shimizu, M. Ueno, T. Ito, T. Tamura, M. Naito, H. Nakashima, M. Kawaguchi, M. Takao, Y. Kawai, N. Osada, K. Ichida, K. Yamamoto, H. Suzuki, N. Shinomiya, I. Inoue, T. Takada, H. Matsuo, Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Ann. Rheum. Dis. 79, 164-166 (2020) (epub ahead of print on Nov 28, 2019.).
    オープンアクセス

  6. J. Boocock, M. Leask, Y. Okada, C. Asian Genetic Epidemiology Network, H. Matsuo, Y. Kawamura, Y. Shi, C. Li, D. B. Mount, A. K. Mandal, W. Wang, M. Cadzow, A. L. Gosling, T. J. Major, J. A. Horsfield, H. K. Choi, T. Fadason, J. O'Sullivan, E. A. Stahl, T. R. Merriman, Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Hum Mol Genet 29(6), 923-943 (2020).

＜2019年＞
  1. A. Nakayama, H. Matsuo, A. Ohtahara, K. Ogino, M. Hakoda, T. Hamada, M. Hosoyamada, S. Yamaguchi, I. Hisatome, K. Ichida, N. Shinomiya, Clinical practice guideline for renal hypouricemia (1st edition). Hum Cell 32, 83-87 (2019).
    研究の紹介　　 オープンアクセス　　 F1000Primeの推奨論文に選出されました

  2. Y. Kawamura, H. Nakaoka, A. Nakayama, Y. Okada, K. Yamamoto, T. Higashino, M. Sakiyama, T. Shimizu, H. Ooyama, K. Ooyama, M. Nagase, Y. Hidaka, Y. Shirahama, K. Hosomichi, Y. Nishida, I. Shimoshikiryo, A. Hishida, S. Katsuura-Kamano, S. Shimizu, M. Kawaguchi, H. Uemura, R. Ibusuki, M. Hara, M. Naito, M. Takao, M. Nakajima, S. Iwasawa, H. Nakashima, K. Ohnaka, T. Nakamura, B. Stiburkova, T. R. Merriman, M. Nakatochi, S. Ichihara, M. Yokota, T. Takada, T. Saitoh, Y. Kamatani, A. Takahashi, K. Arisawa, T. Takezaki, K. Tanaka, K. Wakai, M. Kubo, T. Hosoya, K. Ichida, I. Inoue, N. Shinomiya, H. Matsuo. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Ann. Rheum. Dis. 78, 1430-1437 (2019) (epub ahead of print on Jul. 8, 2019).
    研究の紹介　　 オープンアクセス

  3. M. Nakatochi, M. Kanai, A. Nakayama, A. Hishida, Y. Kawamura, S. Ichihara, M. Akiyama, H. Ikezaki, N. Furusyo, S. Shimizu, K. Yamamoto, M. Hirata, R. Okada, S. Kawai, M. Kawaguchi, Y. Nishida, C. Shimanoe, R. Ibusuki, T. Takezaki, M. Nakajima, M. Takao, E. Ozaki, D. Matsui, T. Nishiyama, S. Suzuki, N. Takashima, Y. Kita, K. Endoh, K. Kuriki, H. Uemura, K. Arisawa, I. Oze, K. Matsuo, Y. Nakamura, H. Mikami, T. Tamura, H. Nakashima, T. Nakamura, N. Kato, K. Matsuda, Y. Murakami, T. Matsubara, M. Naito, M. Kubo, Y. Kamatani, N. Shinomiya, M. Yokota, K. Wakai, Y. Okada, H. Matsuo. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Commun. Biol. 2. 115 (2019).
    研究の紹介　　 オープンアクセス

＜2018年＞
  1. M. Sakiyama, H. Matsuo, H. Nakaoka, Y. Kawamura, M. Kawaguchi, T. Higashino, A. Nakayama, A. Akashi, J. Ueyama, T. Kondo, K. Wakai, Y. Sakurai, K. Yamamoto, H. Ooyama, N. Shinomiya. Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese. BMC Med Genet, 19, 96 (2018)
    オープンアクセス

＜2017年＞
  1. T. Higashino, T. Takada, H. Nakaoka, Y. Toyoda, B. Stiburkova, H. Miyata, Y. Ikebuchi, H. Nakashima, S. Shimizu, M. Kawaguchii, M. Sakiyama, A. Nakayama, A. Akashi, Y. Tanahashi, Y. Kawamura, T. Nakamura, K. Wakai, R. Okada, K. Yamamoto, K. Hosomichi, T. Hosoya, K. Ichida, H. Ooyama, H. Suzuki, I. Inoue, T. R. Merriman, N. Shinomiya, H. Matsuo. Multiple common and rare variants of ABCG2 cause gout. RMD Open, 3, e000464 (2017).
    オープンアクセス

  2. H. Ogata, H. Matsuo, M. Sakiyama, T. Higashino, M. Kawaguchi, A. Nakayama, M. Naito, H. Ooyama, K. Ichida, N. Shinomiya. Meta-analysis confirms an association between gout and a common variant of LRRC16A locus. Mod Rheumatol, 27, 553-555 (2017)
    オープンアクセス

  3. M. Sakiyama, H. Matsuo, A. Akashi, S. Shimizu, T. Higashino, M. Kawaguchi, A. Nakayama, M. Naito, S. Kawai, H. Nakashima, Y. Sakurai, K. Ichida, T. Shimizu, H. Ooyama, N. Shinomiya. Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout. Sci Rep, 7, 2500 (2017).
    研究の紹介　　オープンアクセス

＜2016年＞
  1. A. Nakayama, H. Nakaoka, K. Yamamoto, M. Sakiyama, A. Shaukat, Y. Toyoda, Y. Okada, Y. Kamatani, T. Nakamura, T. Takada, K. Inoue, T. Yasujima, H. Yuasa, Y. Shirahama, H. Nakashima, S. Shimizu, T. Higashino, Y. Kawamura, H. Ogata, M. Kawaguchi, Y. Ohkawa, I. Danjoh, A. Tokumasu, K. Ooyama, T. Ito, T. Kondo, K. Wakai, B. Stiburkova, K. Pavelka, L. K. Stamp, N. Dalbeth, Eurogout Consortium, Y. Sakurai, H. Suzuki, M. Hosoyamada, S. Fujimori, T. Yokoo, T. Hosoya, I. Inoue, A. Takahashi, M. Kubo, H. Ooyama, T. Shimizu, K. Ichida, N. Shinomiya, T. R. Merriman, H. Matsuo. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Ann Rheum Dis, 76, 869-877 (2017). (epub ahead of print, on Nov 29, 2016).
    研究の紹介　　オープンアクセス

  2. H. Matsuo, T. Tsunoda, K. Ooyama, M. Sakiyama, T. Sogo, T. Takada, A. Nakashima, A. Nakayama, M. Kawaguchi, T. Higashino, K. Wakai , H. Ooyama, R. Hokari, H. Suzuki, K. Ichida, A.Inui, S. Fujimori, N. Shinomiya.　Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2.　Sci Rep, 6, 31003 (2016).
    プレスリリース　　オープンアクセス

  3. M. Sakiyama, H. Matsuo, H. Nakaoka, K. Yamamoto, A. Nakayama, T. Nakamura, S. Kawai, R. Okada, H. Ooyama, T. Shimizu, N. Shinomiya. Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus. Sci Rep, 6, 25360 (2016).
    プレスリリース　　オープンアクセス

  4. M. Sakiyama, H. Matsuo, S. Shimizu, H. Nakashima, T. Nakamura, A. Nakayama, T. Higashino, M. Naito, S. Suma, A. Hishida, T. Satoh, Y. Skurai, T. Takada, K. Ichida, H. Ooyama, T. Shimizu, N. Shinomiya, The effects of URAT1/SLC22A12 nonfunctional variants, R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression. Sci Rep, 6, 20148 (2016).
    研究の紹介　　オープンアクセス

  5. Y. Honkura, H. Matsuo, S. Murakami, M. Sakiyama, K. Mizutari, A. Shiotani, M. Yamamoto, I. Morita, N. Shinomiya, T. Kawase, Y. Katori, H. Motohashi, NRF2 is a key target for prevention of noise-induced hearing loss by reducing oxidative damage of cochlea. Sci Rep, 6, 19329 (2016).
    プレスリリース　　オープンアクセス

  6. H. Yokokawa, H. Fukuda, A. Suzuki, K. Fujibayashi, T. Naito, Y. Uehara, A. Nakayama, H. Matsuo, H. Sanada, P. A. Jose, Y. Miwa, T. Hisaoka, H. Isonuma, Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers. J Clin Hypertens (Greenwich), 18, 53-59 (2016).
    オープンアクセス

  7. H. Matsuo, K. Yamamoto, H. Nakaoka, A. Nakayama, M. Sakiyama, T. Chiba, A. Takahashi, T. Nakamura, H. Nakashima, Y. Takada, I. Danjoh, S. Shimizu, J. Abe, Y. Kawamura, S. Terashige, H. Ogata, S. Tatsukawa, G. Yin, R. Okada, E. Morita, M. Naito, A. Tokumasu, H. Onoue, K. Iwaya, T. Ito, T. Takada, K. Inoue, Y. Kato, Y. Nakamura, Y. Sakurai, H. Suzuki, Y. Kanai, T. Hosoya, N. Hamajima, I. Inoue, M. Kubo, K. Ichida, H. Ooyama, T. Shimizu, N. Shinomiya, Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis, 75, 652-659 (2016). (epub ahead of print, on Feb 2, 2015).
    プレスリリース　　オープンアクセス

＜2015年＞
  1. H. Matsuo, K. Yamamoto, H. Nakaoka, A. Nakayama, M. Sakiyama, T. Chiba, A. Takahashi, T. Nakamura, H. Nakashima, Y. Takada, I. Danjoh, S. Shimizu, J. Abe, Y. Kawamura, S. Terashige, H. Ogata, S. Tatsukawa, G. Yin, R. Okada, E. Morita, M. Naito, A. Tokumasu, H. Onoue, K. Iwaya, T. Ito, T. Takada, K. Inoue, Y. Kato, Y. Nakamura, Y. Sakurai, H. Suzuki, Y. Kanai, T. Hosoya, N. Hamajima, I. Inoue, M. Kubo, K. Ichida, H. Ooyama, T. Shimizu, N. Shinomiya, Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis (epub ahead of print).
    プレスリリース　　オープンアクセス

  2. H. Matsuo, H. Tomiyama, W. Satake, T. Chiba, H. Onoue, Y. Kawamura, A. Nakayama, S. Shimizu, M. Sakiyama, M. Funayama, K. Nishioka, T. Shimizu, K. Kaida, K. Kamakura, T. Toda, N. Hattori, N. Shinomiya, ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout. Ann. Clin. Transl. Neurol. 2, 302-306 (2015).
    研究の紹介　　オープンアクセス

  3. T. Chiba, H. Matsuo, Y. Kawamura, S. Nagamori, T. Nishiyama, L. Wei, A. Nakayama, T. Nakamura, M. Sakiyama, T. Takada, Y. Taketani, S. Suma, M. Naito, T. Oda, H. Kumagai, Y. Moriyama, K. Ichida, T. Shimizu, Y. Kanai, N. Shinomiya, NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. Arthritis Rheumatol 67, 281-287 (2015).
    研究の紹介　　オープンアクセス

  4. T. Chiba, H. Matsuo, M. Sakiyama, A. Nakayama, S. Shimizu, K. Wakai, S. Suma, H. Nakashima, Y. Sakurai, T. Shimizu, K. Ichida, N. Shinomiya, Common variant of ALPK1 is not associated with gout: a replication study. Hum. Cell 28, 1-4 (2015).
    オープンアクセス

  5. 中山昌喜, 松尾洋孝, 市田公美, 腎性低尿酸血症とその原因、対策. 最新医学 別冊 高尿酸血症・痛風　診断と治療のABCシリーズ 105, 99-106 (2015).

  6. 松尾洋孝, 高田龍平, トランスポーター及びその薬物との関連について述べよ. カラーイラストで学ぶ　集中講義　薬理学, 16-17 (2015).

  7. M. Taniguchi, H. Matsuo, S. Shimizu, A. Nakayama, K. Suzuki, N. Hamajima, N. Shinomiya, S. Nishio, S. Kosugi, S. Usami, J. Ito, S. Kitajiri, Carrier frequency of the GJB2 mutations that cause hereditary hearing loss in the Japanese population. J. Hum. Genet. 60, 613-617 (2015).
    オープンアクセス

  8. J. Furukawa, K. Inoue, J. Maeda, T. Yasujima, K. Ohta, Y. Kanai, T. Takada, H. Matsuo, H. Yuasa, Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. Sci. Rep. 5, 15057 (2015).
    オープンアクセス

  9. 崎山真幸, 松尾洋孝.　若くして痛風を発症する遺伝子要因.　Bio Clinica 30, 91-94 (2015).

＜2014年＞
  1. A. Nakayama, H. Matsuo, H. Nakaoka, T. Nakamura, H. Nakashima, Y. Takada, Y. Oikawa, T. Takada, M. Sakiyama, S. Shimizu, Y. Kawamura, T. Chiba, J. Abe, K. Wakai, S. Kawai, R. Okada, T. Tamura, Y. Shichijo, A. Akashi, H. Suzuki, T. Hosoya, Y. Sakurai, K. Ichida, N. Shinomiya, Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors. Sci. Rep. 4, 5227 (2014).
    プレスリリース　　オープンアクセス
  2. H. Matsuo, A. Nakayama, M. Sakiyama, T. Chiba, S. Shimizu, Y. Kawamura, H. Nakashima, T. Nakamura, Y. Takada, Y. Oikawa, T. Takada, H. Nakaoka, J. Abe, H. Inoue, K. Wakai, S. Kawai, Y. Guang, H. Nakagawa, T. Ito, K. Niwa, K. Yamamoto, Y. Sakurai, H. Suzuki, T. Hosoya, K. Ichida, T. Shimizu, N. Shinomiya, ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. Sci. Rep. 4, 3755 (2014).
    プレスリリース　　オープンアクセス
  3. Y. Takada, H. Matsuo, A. Nakayama, M. Sakiyama, A. Hishida, R. Okada, Y. Sakurai, T. Shimizu, K. Ichida, N. Shinomiya, Common variant of PDZK1, adaptor protein gene of urate transporters, is not associated with gout. J. Rheumatol. 41, 2330-2331 (2014).
    オープンアクセス
  4. T. Takada, K. Ichida, H. Matsuo, A. Nakayama, K. Murakami, Y. Yamanashi, H. Kasuga, N. Shinomiya, H. Suzuki, ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion. Nucleosides Nucleotides Nucleic Acids 33, 275-281 (2014).

  5. M. Sakiyama, H. Matsuo, Y. Takada, T. Nakamura, A. Nakayama, T. Takada, S. I. Kitajiri, K. Wakai, H. Suzuki, N. Shinomiya, Ethnic differences in ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP): genotype combinations and estimated functions. Drug Metab. Pharmacokinet. 29, 490-492 (2014).
    オープンアクセス
  6. M. Sakiyama, H. Matsuo, S. Shimizu, H. Nakashima, A. Nakayama, T. Chiba, M. Naito, T. Takada, H. Suzuki, N. Hamajima, K. Ichida, T. Shimizu, N. Shinomiya, A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout. Drug Metab. Pharmacokinet. 29, 208-210 (2014).
    オープンアクセス
  7. M. Sakiyama, H. Matsuo, S. Shimizu, T. Chiba, A. Nakayama, Y. Takada, T. Nakamura, T. Takada, E. Morita, M. Naito, K. Wakai, H. Inoue, S. Tatsukawa, J. Sato, K. Shimono, T. Makino, T. Satoh, H. Suzuki, Y. Kanai, N. Hamajima, Y. Sakurai, K. Ichida, T. Shimizu, N. Shinomiya, A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. Hum. Cell 27, 1-4 (2014).
    オープンアクセス
  8. M. Sakiyama, H. Matsuo, T. Chiba, A. Nakayama, T. Nakamura, S. Shimizu, E. Morita, N. Fukuda, H. Nakashima, Y. Sakurai, K. Ichida, T. Shimizu, N. Shinomiya, Common variants of cGKII/PRKG2 are not associated with gout susceptibility. J. Rheumatol. 41, 1395-1397 (2014).
    オープンアクセス
  9. A. Nakayama, H. Matsuo, T. Shimizu, Y. Takada, T. Nakamura, S. Shimizu, T. Chiba, M. Sakiyama, M. Naito, E. Morita, K. Ichida, N. Shinomiya, Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility. Rheumatol. Int. 34, 473-476 (2014).
    オープンアクセス
  10. H. Matsuo, T. Takada, A. Nakayama, T. Shimizu, M. Sakiyama, S. Shimizu, T. Chiba, H. Nakashima, T. Nakamura, Y. Takada, Y. Sakurai, T. Hosoya, N. Shinomiya, K. Ichida, ABCG2 dysfunction increases the risk of renal overload hyperuricemia. Nucleosides Nucleotides Nucleic Acids 33, 266-274 (2014).

  11. T. Chiba, H. Matsuo, S. Nagamori, A. Nakayama, Y. Kawamura, S. Shimizu, M. Sakiyama, M. Hosoyamada, S. Kawai, R. Okada, N. Hamajima, Y. Kanai, N. Shinomiya, Identification of a hypouricemia patient with SLC2A9 R380W, a pathogenic mutation for renal hypouricemia type 2. Nucleosides Nucleotides Nucleic Acids 33, 261-265 (2014).

  12. H. Tsujimoto, Y. Morimoto, R. Takahata, S. Nomura, K. Yoshida, H. Horiguchi, S. Hiraki, S. Ono, H. Miyazaki, D. Saito, Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer. Cancer Sci 105, 1626-1630 (2014).
    プレスリリース　　オープンアクセス
  13. K. Miyazaki, Y. Morimoto, N. Nishiyama, H. Satoh, M. Tanaka, N. Shinomiya, K. Ito, Preconditioning methods influence tumor property in an orthotopic bladder urothelial carcinoma rat model. Mol Clin Oncol 2, 65-70 (2014).
    オープンアクセス
  14. M. Miyamoto, M. Takano, K. Iwaya, N. Shinomiya, M. Kato, T. Aoyama, N. Sasaki, T. Goto, A. Suzuki, J. Hitrata, K. Furuya, X-chromosome-linked inhibitor of apoptosis as a key factor for chemoresistance in clear cell carcinoma of the ovary. Br J Cancer 110, 2881-2886 (2014).

  15. T. Nagata, K. Masumoto, Y. Uchiyama, Y. Watanabe, R. Azuma, Y. Morimoto, F. Katou, Improved technique for evaluating oral free flaps by pinprick testing assisted by indocyanine green near-infrared fluorescence angiography. J Craniomaxillofac Surg. 42, 1112-6 (2014).

  16. S. Iwaki, K. Hokamura, M. Ogawa, Y. Takehara, Y. Muramatsu, T. Yamane, K. Hirabayashi, Y. Morimoto, K. Hagisawa, K. Nakahara, Design Strategy for Small Molecule-based Targeted MRI Contrast Agents: Application for Detection of Atherosclerotic Plaques. Org Biomol Chem 12, 8611-18 (2014).

  17. A. Azhim, N. Syazwani, Y. Morimoto, K. Furukawa, T. Ushida, The use of sonication treatment to decellularize aortic tissues for preparation of bioscaffolds. J Biomater Applications 29, 130-141 (2014).

  18. 高田雄三, 松村耕治, 松尾洋孝, 中山昌喜, 清水聖子, 崎山真幸, 千葉俊周, 四ノ宮成祥, 中島宏, 櫻井裕, 清水徹, 宮平靖, 痛風・高尿酸血症のリスク評価のための迅速遺伝子検査. DNA多型 22, 151-154 (2014).

＜2013年＞
  1. H. Matsuo, K. Ichida, T. Takada, A. Nakayama, H. Nakashima, T. Nakamura, Y. Kawamura, Y. Takada, K. Yamamoto, H. Inoue, Y. Oikawa, M. Naito, A. Hishida, K. Wakai, C. Okada, S. Shimizu, M. Sakiyama, T. Chiba, H. Ogata, K. Niwa, M. Hosoyamada, A. Mori, N. Hamajima, H. Suzuki, Y. Kanai, Y. Sakurai, T. Hosoya, T. Shimizu, N. Shinomiya, Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci. Rep. 3, 2014 (2013).
    プレスリリース　　オープンアクセス
  2. A. Nakayama, H. Matsuo, T. Shimizu, H. Ogata, Y. Takada, H. Nakashima, T. Nakamura, S. Shimizu, T. Chiba, M. Sakiyama, C. Ushiyama, T. Takada, K. Inoue, S. Kawai, A. Hishida, K. Wakai, N. Hamajima, K. Ichida, Y. Sakurai, Y. Kato, N. Shinomiya, A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum. Cell 26, 133-136 (2013).
    オープンアクセス

  3. Y. Takada, H. Matsuo, M. Sakiyama, A. Nakayama, A. Fujii, S. Shimizu, T. Chiba, H. Ogata, H. Nakashima, K. Matsumura, K. Suzuki, N. Hamajima, K. Niwa, S. Suzuki, S. Uchino, Y. Sakurai, Y. Kobayashi, N. Shinomiya, ABCG2 SNP typing using HRM assay : Effective approach for gout and hyperuricemia risk evaluation. J. Clin. Welfare 10, 64-69 (2013).

  4. Y. Hinohara, M. Naito, R. Okada, G. Yin, T. Higashibata, T. Tamura, S. Kawai, E. Morita, K. Wakai, H. Matsuo, A. Mori, N. Hamajima, No association between MTHFR C677T and serum uric acid levels among Japanese with ABCG2 126QQ and SLC22A12 258WW. Nagoya J. Med. Sci. 75, 93-100 (2013).

  5. S. Takeuchi, K. Wada, T. Toyooka, N. Shinomiya, H. Shimazaki, K. Nakanishi, K. Nagatani, N. Otani, H. Osada, Y. Uozumi, H. Matsuo, H. Nawashiro, Increased xCT expression correlates with tumor invasion and outcome in patients with glioblastomas. Neurosurgery 72, 33-41; discussion 41 (2013).

  6. Q. Xie, Y. Su, K. Dykema, J. Johnson, J. Koeman, V. De Giorgi, A. Huang, R. Schlegel, C. Essenburg, L. Kang, K. Iwaya, S. Seki, S. K. Khoo, B. Zhang, F. Buonaguro, F. M. Marincola, K. Furge, G. F. Vande Woude, N. Shinomiya, Overexpression of HGF Promotes HBV-Induced Hepatocellular Carcinoma Progression and Is an Effective Indicator for Met-Targeting Therapy. Genes Cancer 4, 247-260 (2013).

  7. M. Tanaka, P. Mroz, T. Dai, L. Huang, Y. Morimoto, M. Kinoshita, Y. Yoshihara, N. Shinomiya, S. Seki, K. Nemoto, M. R. Hamblin, Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis. Photochem Photobiol 89, 679-682 (2013).

  8. S. Takeuchi, K. Wada, T. Toyooka, N. Shinomiya, H. Shimazaki, K. Nakanishi, K. Nagatani, N. Otani, H. Osada, Y. Uozumi, H. Matsuo, H. Nawashiro, Increased xCT expression correlates with tumor invasion and outcome in patients with glioblastomas. Neurosurgery 72, 33-41; discussion 41 (2013).

  9. N. Shinomiya, M. Minehata, M. Dando, Bioweapons and Dual-Use Research of Concern. J Disaster Res 8, 654-666 (2013).

  10. M. Minehata, J. Sture, N. Shinomiya, S. Whitby, M. Dando, Promoting Education of Dual-Use Issues for Life Scientists: A Comprehensive Approach. J Disaster Res 8, 674-685 (2013).

  11. M. Minehata, J. Sture, N. Shinomiya, S. Whitby, Implementing biosecurity education: approaches, resources and programmes. Sci Eng Ethics 19, 1473-1486 (2013).

  12. M. Takai, M. Nagai, Y. Morimoto, K. Sasao, A. Oki, J. Nakanishi, H. Inokuchi, C.-H. Chang, J. Kikuchi, H. Ogawa, Colorimetric microchip assay using our own whole blood collected by a painless needle for home medical care. Analyst 138, 6469-6476 (2013).

  13. H. Mutai, N. Suzuki, A. Shimizu, C. Torii, K. Namba, N. Morimoto, J. Kudoh, K. Kaga, K. Kosaki, T. Matsunaga, Diverse spectrum of rare deafness genes underlies early-childhood hearing loss in Japanese patients: a cross-sectional, multi-center next-generation sequencing study. Orphanet J Rare Dis 8, 172 (2013).

  14. 中山昌喜, 松尾洋孝, 高田龍平, 市田公美, 四ノ宮成祥, 【日本が貢献した世界的新知見】 ABCG2と高尿酸血症. 高尿酸血症と痛風 21, 43-48 (2013).

  15. 高田雄三, 松村耕治, 小林靖, 松尾洋孝, 中山昌喜, 四ノ宮成祥, 中島宏, 櫻井裕, 鈴木康司, 濱嶋信之, 全自動SNPタイピング装置を利用した痛風の遺伝子タイピング. DNA多型 21, 256-260 (2013).

  16. 森谷邦彦, 鈴木淳美, 鈴木大, 浅田洋司, 根本照子, 鈴木保志朗, 藤江弘美, 鈴木潤, 阿部淳子, 清水聖子, 松尾洋孝, 四ノ宮成祥, 腰痛を主訴に来院し、遺伝子解析により腎性低尿酸血症1型と診断された1例. 小児科臨床 66, 1930-1932 (2013).

  17. 千葉俊周, 松尾洋孝, 市田公美, 四ノ宮成祥, 尿酸代謝におけるUp-to-Date(第8回)　痛風の遺伝子、基礎から臨床へ. 医薬の門 53, 74-79 (2013).

  18. 高田龍平, 松尾洋孝, 市田公美, 尿酸排出トランスポーターと高尿酸血症の新たな発症メカニズム. 日本医事新報, 48-49 (2013).

  19. 高田龍平, 松尾洋孝, 【トランスポーターと疾患研究の最前線】 トランスポーターと疾患【尿酸】 ABCトランスポーターによる尿酸輸送. 医学のあゆみ 245, 11-15 (2013).

＜2012年＞
  1. K. Ichida, H. Matsuo, T. Takada, A. Nakayama, K. Murakami, T. Shimizu, Y. Yamanashi, H. Kasuga, H. Nakashima, T. Nakamura, Y. Takada, Y. Kawamura, H. Inoue, C. Okada, Y. Utsumi, Y. Ikebuchi, K. Ito, M. Nakamura, Y. Shinohara, M. Hosoyamada, Y. Sakurai, N. Shinomiya, T. Hosoya, H. Suzuki, Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat. Commun. 3, 764 (2012).
    プレスリリース　　オープンアクセス
  2. N. Hamajima, M. Naito, R. Okada, S. Kawai, G. Yin, E. Morita, T. Higashibata, T. Tamura, H. Nakagawa, H. Matsuo, A. Mori, K. Wakai, Significant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese population. Gene 503, 131-136 (2012).

  3. S. Takeuchi, H. Nawashiro, K. Wada, N. Nomura, T. Toyooka, N. Otani, H. Osada, H. Matsuo, N. Shinomiya, L-Leucine induces growth arrest and persistent ERK activation in glioma cells. Amino Acids 43, 717-724 (2012).

  4. M. Tanaka, P. Mroz, T. Dai, L. Huang, Y. Morimoto, M. Kinoshita, Y. Yoshihara, K. Nemoto, N. Shinomiya, S. Seki, M. R. Hamblin, Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation. PLoS One 7, e39823 (2012).
    プレスリリース　　オープンアクセス
  5. M. Tanaka, M. Kinoshita, Y. Yoshihara, N. Shinomiya, S. Seki, K. Nemoto, T. Hirayama, T. Dai, L. Huang, M. R. Hamblin, Y. Morimoto, Optimal photosensitizers for photodynamic therapy of infections should kill bacteria but spare neutrophils. Photochem Photobiol 88, 227-232 (2012).

  6. M. Tanaka, M. Kinoshita, Y. Yoshihara, N. Shinomiya, S. Seki, K. Nemoto, T. Hirayama, T. Dai, L. Huang, M. R. Hamblin, Y. Morimoto, Optimal photosensitizers for photodynamic therapy of infections should kill bacteria but spare neutrophils. Photochem Photobiol 88, 227-232 (2012).

  7. J. Sture, M. Minehata, N. Shinomiya, Looking at the formulation of national biosecurity education action plans. Med Confl Surviv 28, 85-97 (2012).

  8. N. Shinomiya, [Infectious diseases: progress in diagnosis and treatment. Topics: I. Infectious diseases in unusual circumstances: 3. The possibility of bioterrorism and its countermeasures]. Nihon Naika Gakkai Zasshi 101, 3103-3113 (2012).

  9. M. Nakashima, M. Kinoshita, H. Nakashima, Y. Habu, H. Miyazaki, S. Shono, S. Hiroi, N. Shinomiya, K. Nakanishi, S. Seki, Pivotal Advance: Characterization of mouse liver phagocytic B cells in innate immunity. J Leukoc Biol 91, 537-546 (2012).

  10. K. Miyazaki, Y. Morimoto, N. Nishiyama, Y. Maekawa, W. Z. Hu, K. Nakatate, K. Kaneda, N. Shinomiya, K. Kataoka, A novel homogeneous irradiation fiber probe for whole bladder wall photodynamic therapy. Lasers Surg Med 44, 413-420 (2012).

  11. K. Miyazaki, Y. Morimoto, N. Nishiyama, Y. Maekawa, W. Z. Hu, K. Nakatate, K. Kaneda, N. Shinomiya, K. Kataoka, A novel homogeneous irradiation fiber probe for whole bladder wall photodynamic therapy. Lasers Surg Med 44, 413-420 (2012).

  12. Y. Takagi, T. Kunishi, T. Katayama, Y. Ishibashi, H. Miyasaka, M. Morimoto, M. Irie, Photoswitchable fluorescent diarylethene derivatives with short alkyl chain substituents. Photochem Photobiol Sci 11, 1661-1665 (2012).

  13. T. Ikeda, A. Morimoto, S. Nakamura, K. Yokoyama, T. Hayase, Y. Oh, Y. Kashii, S. Yotsumoto, H. Okamoto, Y. M. M, A marked decrease in CD4-positive lymphocytes at the onset of hepatitis in a patient with hepatitis-associated aplastic anemia. J Pediat Hematol 34, 375-377 (2012).

  14. Y. Y. Huang, M. Tanaka, D. Vecchio, M. Garcia-Diaz, J. Chang, Y. Morimoto, M. R. Hamblin, Photodynamic therapy induces an immune response against a bacterial pathogen. Exp Rev Clin Immun 8, 479-494 (2012).

  15. M. Beam, M. C. Silva, R. I. Morimoto, Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo. J Biol Chem 287, 26136-26145 (2012).

  16. 高田雄三, 松村耕治, 松尾洋孝, 井上寛規, 中山昌喜, 四ノ宮成祥, 藤井安宇美, 丹羽和紀, 鈴木康司, 濱嶋信之, 小林靖, High Resolution Melting法によるABCG2遺伝子のSNPタイピング. DNA多型 20, 286-290 (2012).

  17. 中山昌喜, 松尾洋孝, 市田公美, 四ノ宮成祥, 【腎疾患治療マニュアル2012-13】 尿細管疾患　尿細管機能異常症　腎性低尿酸血症. 腎と透析 72, 370-373 (2012).

  18. 千葉俊周, 松尾洋孝, 中山昌喜, 市田公美, 四ノ宮成祥, XV 膜輸送系の異常 遺伝性腎性低尿酸血症. 別冊 日本臨床 (日本臨床社, 大阪, ed. 2, 2012), vol. 新領域別症候群シリーズ 20, pp. 807-811.

  19. 千葉俊周, 松尾洋孝, 市田公美, 四ノ宮成祥, 【高尿酸血症・低尿酸血症Q&A】 低尿酸血症の頻度、原因、分類を教えてください. 腎と透析 73, 301-304 (2012).

  20. 松尾洋孝, 市田公美, 高田龍平, 中山昌喜, 四ノ宮成祥, 尿酸動態の支配要因としての尿酸トランスポーター. 細胞工学 31, 553-557 (2012).

  21. 松尾洋孝, 四ノ宮成祥, 代謝　臨床分野での進歩 腎性低尿酸血症の遺伝学. Annual Review糖尿病・代謝・内分泌 2012, 145-154 (2012).

  22. 松尾洋孝, 【臨床医のための高尿酸血症・痛風のABC】 その他　痛風の遺伝素因を教えてください. 高尿酸血症と痛風 20, 84-86 (2012).

＜2011年＞
  1. Y. Kawamura, H. Matsuo, T. Chiba, S. Nagamori, A. Nakayama, H. Inoue, Y. Utsumi, T. Oda, J. Nishiyama, Y. Kanai, N. Shinomiya, Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2). Nucleosides Nucleotides Nucleic Acids 30, 1105-1111 (2011).

  2. A. Nakayama, H. Matsuo, T. Takada, K. Ichida, T. Nakamura, Y. Ikebuchi, K. Ito, T. Hosoya, Y. Kanai, H. Suzuki, N. Shinomiya, ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans. Nucleosides Nucleotides Nucleic Acids 30, 1091-1097 (2011).

  3. H. Matsuo, T. Takada, K. Ichida, T. Nakamura, A. Nakayama, Y. Takada, C. Okada, Y. Sakurai, T. Hosoya, Y. Kanai, H. Suzuki, N. Shinomiya, Identification of ABCG2 dysfunction as a major factor contributing to gout. Nucleosides Nucleotides Nucleic Acids 30, 1098-1104 (2011).

  4. H. Matsuo, T. Takada, K. Ichida, T. Nakamura, A. Nakayama, H. Suzuki, T. Hosoya, N. Shinomiya, ABCG2/BCRP dysfunction as a major cause of gout. Nucleosides Nucleotides Nucleic Acids 30, 1117-1128 (2011).

  5. N. Hamajima, R. Okada, S. Kawai, A. Hishida, E. Morita, G. Yin, K. Wakai, H. Matsuo, H. Inoue, Y. Takada, Y. Asai, A. Mori, M. Naito, Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population. Mol. Genet. Metab. 103, 378-382 (2011).

  6. T. Toyooka, H. Nawashiro, N. Shinomiya, K. Shima, Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats. J Neurotrauma 28, 607-618 (2011).

  7. M. Tanaka, M. Kinoshita, Y. Yoshihara, N. Shinomiya, S. Seki, K. Nemoto, M. R. Hamblin, Y. Morimoto, Photodynamic therapy using intra-articular Photofrin for murine MRSA arthritis: biphasic light dose response for neutrophil-mediated antibacterial effect. Lasers Surg Med 43, 221-229 (2011).

  8. S. Takeuchi, H. Nawashiro, K. Wada, N. Nomura, T. Toyooka, N. Otani, H. Osada, H. Matsuo, N. Shinomiya, L: -Leucine induces growth arrest and persistent ERK activation in glioma cells. Amino Acids, (2011).

  9. S. Shono, Y. Habu, M. Nakashima, A. Sato, H. Nakashima, H. Miyazaki, M. Kinoshita, G. Tsumatori, N. Shinomiya, S. Seki, The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat and high-cholesterol diet. Shock 36, 484-493 (2011).

  10. H. Nawashiro, N. Shinomiya, Everolimus and giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 364, 576-577; author reply 577 (2011).

  11. M. Minehata, J. Sture, N. Shinomiya, S. Whitby, Implementing Biosecurity Education: Approaches, Resources and Programmes. Sci Eng Ethics (2011).

  12. M. Kinoshita, H. Miyazaki, S. Ono, A. Inatsu, H. Nakashima, H. Tsujimoto, N. Shinomiya, D. Saitoh, S. Seki, Enhancement of Neutrophil Function by Interleukin-18 Therapy Protects Burn-Injured Mice from Methicillin-Resistant Staphylococcus aureus. Infect Immun 79, 2670-2680 (2011).

  13. M. Fujita, H. Sato, K. Kaku, S. Tokuno, Y. Kanatani, S. Suzuki, N. Shinomiya, Airport quarantine inspection, follow-up observation, and the prevention of pandemic influenza. Aviat Space Environ Med 82, 782-789 (2011).

  14. S. Herlambang, M. Kumagai, T. Nomoto, S. Horie, S. Fukushima, M. Oba, K. Miyazaki, Y. Morimoto, N. Nishiyama, K. Kataoka, Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy. J Control Release 155, 449-457 (2011).

  15. 松尾洋孝, 【トランスポートソーム　生体膜輸送機構の全体像に迫る　基礎、臨床、創薬応用研究の最新成果】 残されたトランスポーターへのアプローチ　トランスポーターの分子機能を指標とした臨床遺伝学的解析による痛風の主要病因遺伝子ABCG2の同定. 遺伝子医学MOOK, 116-125 (2011).

  16. 松尾洋孝, 【尿酸】 高尿酸血症と腎輸送体. 腎臓 34, 16-22 (2011).

  17. 松尾洋孝, 第7章 尿酸のトランスポーター in 栄養・食品機能とトランスポーター, 日本栄養・食糧学会 監修, 竹谷豊, 薩秀夫, 伊藤美紀子, 武田英二, Eds. (建帛社, 東京, 2011), pp. 145-166.

  18. 松尾洋孝, 3-2-4 尿酸輸送 in トランスポートソームの世界 -膜輸送研究の源流から未来へ-, 金井好克, 竹島浩, 森泰生, 久保義弘, Eds. (特定領域研究「生体膜トランスポートソームの分子構築と生理機能」事務局, 大阪, 2011) pp. 179-191.

  19. 高田龍平, 松尾洋孝, 尿酸排出トランスポーターABCG2/BCRPと痛風発症リスク. 生化学 83, 1131-1135 (2011).

  20. 高田雄三, 松尾洋孝, 痛風・高尿酸血症の原因遺伝子(ABCG2). Medical Technology 39, 884-886 (2011).

＜2010年＞
  1. S. Watanabe, H. Matsuo, Y. Kobayashi, Y. Satoh, M. Fujita, A. Nakayama, Y. Aizawa, N. Shinomiya, S. Suzuki, Transient degradation of myelin basic protein in the rat hippocampus following acute carbon monoxide poisoning. Neurosci. Res. 68, 232-240 (2010).

  2. K. Takeuchi, S. Ogata, K. Nakanishi, Y. Ozeki, S. Hiroi, S. Tominaga, S. Aida, H. Matsuo, T. Sakata, T. Kawai, LAT1 expression in non-small-cell lung carcinomas: analyses by semiquantitative reverse transcription-PCR (237 cases) and immunohistochemistry (295 cases). Lung Cancer 68, 58-65 (2010).

  3. T. Yamamoto, M. Kinoshita, N. Shinomiya, S. Hiroi, H. Sugasawa, Y. Matsushita, T. Majima, D. Saitoh, S. Seki, Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation. J Radiat Res (Tokyo) 51, 145-156 (2010).

  4. M. Tanaka, M. Kinoshita, Y. Yoshihara, N. Shinomiya, S. Seki, K. Nemoto, Y. Morimoto, Influence of intra-articular neutrophils on the effects of photodynamic therapy for murine MRSA arthritis. Photochem Photobiol 86, 403-409 (2010).

  5. A. Hirao, S. Sato, D. Saitoh, N. Shinomiya, H. Ashida, M. Obara, In vivo photoacoustic monitoring of photosensitizer distribution in burned skin for antibacterial photodynamic therapy. Photochem Photobiol 86, 426-430 (2010).

  6. Y. Morimoto, M. Tanaka, K. Kinoshita, Photodynamic therapy with preserved immune system – Expectation for treatment for localized bacterial infection. in Photobiology: Principles, Applications and Effects, L. Collignon, C. Normand, Eds. (NOVA, 2010) pp. 269-271 (2010).

  7. Y. Morimoto, K. Matsumura, N. Nakagishi, S. Kawauchi, Transcriptional changes in energy metabolism and protein synthesis predominate in the early phase after photodynamic therapy in Photobiology: Principles, Applications and Effects, L. Collignon, C. Normand, Eds. (NOVA, 2010) pp. 219-232.

  8. N. Morimoto, H. Taiji, K. Tsukamoto, Y. Morimoto, T. Nakamura, T. Hommura, Y. Ito, Risk factors for elevation of ABR threshold in NICU-treated infants. Int J Pediatr Otorhinolaryngol 74, 786-790 (2010).

  9. T. Horio, M. Ishihara, M. Fujita, S. Kishimoto, Y. Kanatani, T. Ishizuka, Y. Nogami, S. Nakamura, Y. Tanaka, Y. Morimoto, T. Maehara, Effect of photocrosslinkable chitosan hydrogel and its sponges to stop bleeding in a rat liver injury model. Artificial organs 34, 342-347 (2010).

  10. R. Azuma, M. Takikawa, S. Nakamura, K. Sasaki, S. Yanagibayashi, N. Yamamoto, T. Kiyosawa, Y. Morimoto, Indocyanine Green Fluorography in Plastic Surgery and Microvascular Surgery. Open Surg Oncol J 2, 48-56 (2010).

  11. 中山昌喜, 松尾洋孝, 四ノ宮成祥, 痛風の遺伝子. リウマチ科 44, 689-694 (2010).

  12. 中山昌喜, 松尾洋孝, 四ノ宮成祥, 【痛風診療最前線】 発症原因　遺伝要因. Modern Physician 30, 1385-1388 (2010).

  13. 松尾洋孝, 市田公美, 症例検討　症例を読む(第29回)　GLUT9の異常症. 高尿酸血症と痛風 18, 84-89 (2010).

  14. 松尾洋孝, 高田龍平, 市田公美, 中村好宏, 鈴木洋史, 四ノ宮成祥, 痛風の主要な病因遺伝子ABCG2の同定. in 実験医学. (羊土社, 東京, 2010), vol. 28, pp. 1285-1289.

  15. 松尾洋孝, 尿酸の再吸収機構と輸送体病　ゲノムワイド関連解析後の新展開. Annual Review腎臓 2010 2010, 9-20 (2010).

  16. 松尾洋孝, 痛風の病因遺伝子. in 痛風と核酸代謝. (2010), vol. 34, pp. 159-169.

＜2009年＞
  1. H. Matsuo, T. Takada, K. Ichida, T. Nakamura, A. Nakayama, Y. Ikebuchi, K. Ito, Y. Kusanagi, T. Chiba, S. Tadokoro, Y. Takada, Y. Oikawa, H. Inoue, K. Suzuki, R. Okada, J. Nishiyama, H. Domoto, S. Watanabe, M. Fujita, Y. Morimoto, M. Naito, K. Nishio, A. Hishida, K. Wakai, Y. Asai, K. Niwa, K. Kamakura, S. Nonoyama, Y. Sakurai, T. Hosoya, Y. Kanai, H. Suzuki, N. Hamajima, N. Shinomiya, Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. Sci. Transl. Med. 1, 5ra11 (2009).
    プレスリリース
  2. A. Matsumoto, H. Tsujimoto, S. Ono, M. Kinoshita, Y. Habu, T. Kawabata, N. Shinomiya, S. Seki, Loss of hepatic B cells following lipopolysaccharide injection and polymicrobial sepsis. J Gastroenterol Hepatol 24, 262-269 (2009).

  3. T. Shimizu, K. Nakai, Y. Morimoto, M. Ishihara, H. Oishi, M. Kikuchi, H. Arai, Simple rabbit model of vulnerable atherosclerotic plaque. Neurologia medico-chirurgica 49, 327-332; discussion 332 (2009).

  4. N. Nishiyama, Y. Nakagishi, Y. Morimoto, P. S. Lai, K. Miyazaki, K. Urano, S. Horie, M. Kumagai, S. Fukushima, Y. Cheng, W. D. Jang, M. Kikuchi, K. Kataoka, Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. J Control Release 133, 245-251 (2009).

  5. N. Nishiyama, Y. Morimoto, W.-D. Jang, K. Kataoka, Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy. Adv Drug Deliv Rev 61, 327-338 (2009).

  6. Y. Nakagishi, N. Morimoto, M. Fujita, Y. Ozeki, T. Maehara, M. Kikuchi, Y. Morimoto, Amelioration of airway stenosis in rabbit models by photodynamic therapy with talaporfin sodium (NPe6). Photochem Photobiol 85, 714-718 (2009).

＜2008年＞
  1. H. Matsuo, T. Chiba, S. Nagamori, A. Nakayama, H. Domoto, K. Phetdee, P. Wiriyasermkul, Y. Kikuchi, T. Oda, J. Nishiyama, T. Nakamura, Y. Morimoto, K. Kamakura, Y. Sakurai, S. Nonoyama, Y. Kanai, N. Shinomiya, Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am. J. Hum. Genet. 83, 744-751 (2008).

  2. T. Toyooka, H. Nawashiro, N. Shinomiya, A. Yano, H. Ooigawa, A. Ohsumi, Y. Uozumi, Y. Yanagawa, H. Matsuo, K. Shima, in Intracranial Pressure and Brain Monitoring., G. Manley, G. Hemphill, S. Stiver, Eds. (Springer Wien, New York, 2008), vol. XIII, pp. 385-399.

  3. K. Sato, N. Shinomiya, [Identification of four species of human malaria parasites by fast PCR]. Rinsho Byori 56, 657-661 (2008).

  4. H. Nakashima, M. Kinoshita, M. Nakashima, Y. Habu, S. Shono, T. Uchida, N. Shinomiya, S. Seki, Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice. Hepatology 48, 1979-1988 (2008).

  5. T. Kawabata, M. Kinoshita, A. Inatsu, Y. Habu, H. Nakashima, N. Shinomiya, S. Seki, Functional alterations of liver innate immunity of mice with aging in response to CpG-oligodeoxynucleotide. Hepatology 48, 1586-1597 (2008).

  6. K. Chochi, T. Ichikura, M. Kinoshita, T. Majima, N. Shinomiya, H. Tsujimoto, T. Kawabata, H. Sugasawa, S. Ono, S. Seki, H. Mochizuki, Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells. Clin Cancer Res 14, 2909-2917 (2008).

  7. T. Oura, H. Tanaka, Y. Morimoto, K. Masumoto, E. Kohno, T. Hirano, F. Katou, K. Hashimoto, Sufficient PpIX production for PDT even with short contact time of topically applied 5-ALA in rabbit tongues. Lasers Med Sci 23, 355-360 (2008).

  8. Y. Nakagishi, Y. Morimoto, M. Fujita, N. Morimoto, Y. Ozeki, T. Maehara, M. Kikuchi, Photodynamic therapy for airway stenosis in rabbit models. Chest 133, 123-130 (2008).

  9. J. Iizuka, Y. Morimoto, Y. Nakagishi, M. Kikuchi, M. Masuzawa, Anti-tumor effect of PDT using Photofrin in a mouse angiosarcoma model. Arch Dermatol Res 300, 161-166 (2008).

  10. R. Azuma, Y. Morimoto, K. Masumoto, M. Nambu, M. Takikawa, S. Yanagibayashi, N. Yamamoto, M. Kikuchi, T. Kiyosawa, Detection of skin perforators by indocyanine green fluorescence nearly infrared angiography. Plast Reconstr Surg 122, 1062-1067 (2008).

＜2007年＞
  1. T. Uchida, M. Kinoshita, M. Fukasawa, Y. Habu, N. Shinomiya, S. Seki, IL-18 time-dependently modulates Th1/Th2 cytokine production by ligand-activated NKT cells. Eur J Immunol 37, 966-977 (2007).

  2. E. Takahashi, N. Kuranaga, K. Satoh, Y. Habu, N. Shinomiya, T. Asano, S. Seki, M. Hayakawa, Induction of CD16+ CD56bright NK cells with antitumour cytotoxicity not only from CD16- CD56bright NK Cells but also from CD16- CD56dim NK cells. Scand J Immunol 65, 126-138 (2007).

  3. K. Sawada, A. R. Radjabi, N. Shinomiya, E. Kistner, H. Kenny, A. R. Becker, M. A. Turkyilmaz, R. Salgia, S. D. Yamada, G. F. Vande Woude, M. S. Tretiakova, E. Lengyel, c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 67, 1670-1679 (2007).

  4. Y. Habu, N. Shinomiya, M. Kinoshita, A. Matsumoto, T. Kawabata, S. Seki, Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. Clin Exp Med 7, 30-38 (2007).

  5. H. Satoh, Y. Morimoto, T. Arai, H. Asanuma, S. Kawauchi, K. Seguchi, M. Kikuchi, M. Murai, Intravesical ultrasonography for tumor staging in an orthotopically implanted rat model of bladder cancer. J Urol 177, 1169-1173 (2007).

  6. F. Ogata, M. Narushima, M. Mihara, R. Azuma, Y. Morimoto, I. Koshima, Intraoperative lymphography using indocyanine green dye for near-infrared fluorescence labeling in lymphedema. Ann Plast Surg 59, 180-184 (2007).

  7. F. Ogata, R. Azuma, M. Kikuchi, I. Koshima, Y. Morimoto, Novel lymphography using indocyanine green dye for near-infrared fluorescence labeling. Ann Plast Surg 58, 652-655 (2007).

  8. Y. Nakagishi, Y. Morimoto, M. Fujita, Y. Ozeki, T. Maehara, M. Kikuchi, Accumulation of photofrin in lesions of airway stenosis rabbit models. Photochem Photobiol 83, 1220-1225 (2007).

  9. Y. Li, W. D. Jang, N. Nishiyama, A. Kishimura, S. Kawauchi, Y. Morimoto, S. Miake, T. Yamashita, M. Kikuchi, T. Aida, K. Kataoka, Dendrimer generation effects on photodynamic efficacy of dendrimer porphyrins and dendrimer-loaded supramolecular nanocarriers. Chem Mater 19, 5557-5562 (2007).

  10. S. Kohyama, Y. Morimoto, K. Nakai, T. Kaji, A. Tokumaru, H. Nawashiro, K. Shima, Y. Satoh, K. Takishima, M. Kikuchi, H. Matsuo, Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Lasers Surg Med 39, 659-666 (2007).

  11. M. Fujita, M. Ishihara, M. Shimizu, K. Obara, S. Nakamura, Y. Kanatani, Y. Morimoto, B. Takase, T. Matsui, M. Kikuchi, T. Maehara, Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia model. Wound repair regenerat 15, 58-65 (2007).

  12. K. Nakanishi, S. Ogata, H. Matsuo, Y. Kanai, H. Endou, S. Hiroi, S. Tominaga, S. Aida, H. Kasamatsu, T. Kawai, Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. Virchows Arch. 451, 681-690 (2007).

  13. N. Kondoh, N. Imazeki, M. Arai, A. Hada, K. Hatsuse, H. Matsuo, O. Matsubara, S. Ohkura, M. Yamamoto, Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. Int. J. Oncol. 31, 81-87 (2007).

＜2006年＞ 　（本講座は2006年に創設されました）
  1. H. Nawashiro, N. Otani, N. Shinomiya, S. Fukui, H. Ooigawa, K. Shima, H. Matsuo, Y. Kanai, H. Endou, L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int J Cancer 119, 484-492 (2006).

  2. H. Nakashima, T. Inui, Y. Habu, M. Kinoshita, S. Nagao, A. Kawaguchi, S. Miura, N. Shinomiya, H. Yagita, S. Seki, Activation of mouse natural killer T cells accelerates liver regeneration after partial hepatectomy. Gastroenterology 131, 1573-1583 (2006).

  3. H. Murakami, N. Shinomiya, T. Kikuchi, Y. Yoshihara, K. Nemoto, Upregulated expression of inducible nitric oxide synthase plays a key role in early apoptosis after anterior cruciate ligament injury. J Orthop Res 24, 1521-1534 (2006).

  4. A. Motegi, M. Kinoshita, K. Sato, N. Shinomiya, S. Ono, S. Nonoyama, H. Hiraide, S. Seki, An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. J Leukoc Biol 79, 463-472 (2006).

  5. A. Matsumoto, M. Kinoshita, S. Ono, H. Tsujimoto, T. Majima, Y. Habu, N. Shinomiya, S. Seki, Cooperative IFN-gamma production of mouse liver B cells and natural killer cells stimulated with lipopolysaccharide. J Hepatol 45, 290-298 (2006).

  6. N. Kuranaga, M. Kinoshita, T. Kawabata, Y. Habu, N. Shinomiya, S. Seki, Interleukin-18 protects splenectomized mice from lethal Streptococcus pneumoniae sepsis independent of interferon-gamma by inducing IgM production. J Infect Dis 194, 993-1002 (2006).

  7. M. Kinoshita, N. Shinomiya, S. Ono, H. Tsujimoto, T. Kawabata, A. Matsumoto, H. Hiraide, S. Seki, Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa. J Immunol 177, 4627-4635 (2006).

  8. M. Kinoshita, N. Kuranaga, A. Matsumoto, S. Ono, N. Shinomiya, H. Hiraide, S. Seki, Multiple interleukin-18 injections promote both mouse Th1 and Th2 responses after sublethal Escherichia coli infection. Clin Exp Immunol 143, 41-49 (2006).

  9. Y. Nakagishi, Y. Morimoto, S. Kawauchi, W. D. Jang, N. Nishiyama, Y. Ozeki, T. Maehara, K. Kataoka, M. Kikuchi, Application of macromolecular polymeric micelles for photodynamic therapy. J Jpn Soc Laser Surg Med 27, 71-76 (2006).

  10. N. Morimoto, T. Tanaka, H. Taiji, R. Horikawa, Y. Naiki, Y. Morimoto, N. Kawashiro, Hearing loss in Turner syndrome. J Pediatr 149, 697-701 (2006).

  11. S. Kawauchi, S. Sato, Y. Morimoto, M. Kikuchi, Intracellular kinetics of ATX-S10.Na(II) and its correlation with photochemical reaction dynamics during a pulsed photosensitization process: effect of pulse repetition rate. J Biomed Opt 11, 014005 (2006).

  12. W. D. Jang, Y. Nakagishi, N. Nishiyama, S. Kawauchi, Y. Morimoto, M. Kikuchi, K. Kataoka, Polyion complex micelles for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property. J Control Release 113, 73-79 (2006).

  13. Y. Shigeta, Y. Kanai, A. Chairoungdua, N. Ahmed, S. Sakamoto, H. Matsuo, D. K. Kim, M. Fujimura, N. Anzai, K. Mizoguchi, T. Ueda, K. Akakura, T. Ichikawa, H. Ito, H. Endou, A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter. Kidney Int. 69, 1198-1206 (2006).

  14. H. Nawashiro, N. Otani, N. Shinomiya, S. Fukui, H. Ooigawa, K. Shima, H. Matsuo, Y. Kanai, H. Endou, L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int. J. Cancer 119, 484-492 (2006).