河村優輔の業績一覧

・論文

<痛風・高尿酸血症、低尿酸血症関連>

  1. M. Kawaguchi, A. Nakayama, Y. Aoyagi, T. Nakamura, S. Shimizu, Y. Kawamura, M. Takao, T. Tamura, A. Hishida, M. Nagayoshi, M. Nagase, K. Ooyama, H. Ooyama, N. Shinomiya, H. Matsuo. Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. Hum Cell. (2021). online ahead of print..

  2. Y. Toyoda, T. Takada, H. Miyata, H. Matsuo, H. Kassai, K Nakao, M. Nakatochi, Y. Kawamura, S. Shimizu, N. Shinomiya, K. Ichida, M. Hosoyamada, A. Aiba, H. Suzuki. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Proc Natl Acad Sci U S A. 117(31):18175-18177 (2020)..

  3. Y. Kawamura, Y. Toyoda, T. Ohnishi, R. Hisatomi, T. Higashino, A. Nakayama, S. Shimizu, M. Yanagi, I. Kamimaki, R. Fujimaru, H. Suzuki, N. Shinomiya, T. Takada, H. Matsuo. Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families. Rheumatology (Oxford), 59(12):3988-3990 (2020)..

  4. A. Nakayama, M. Nakatochi, Y. Kawamura, K. Yamamoto, H. Nakaoka, S. Shimizu, T. Higashino, T. Koyama, A. Hishida, K. Kuriki, M. Watanabe, T. Shimizu, K. Ooyama, H. Ooyama, M. Nagase, Y. Hidaka, D. Matsui, T. Tamura, T. Nishiyama, C. Shimanoe, S. Katsuura-Kamano, N. Takashima, Y. Shirai, M. Kawaguchi, M. Takao, R. Sugiyama, Y. Takada, T. Nakamura, H. Nakashima, M. Tsunoda, I. Danjoh, A. Hozawa, K. Hosomichi, Y. Toyoda, Y. Kubota, T. Takada, H. Suzuki, Blanka Stiburkova, T. J. Major, T. R. Merriman, N. Kuriyama, H. Mikami, T. Takezaki, K. Matsuo, S. Suzuki, T. Hosoya, Y. Kamatani, M. Kubo, K. Ichida, K. Wakai, I. Inoue, Y. Okada, N. Shinomiya, H. Matsuo on behalf of Japan Gout Genomics Consortium (Japan Gout). Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. Ann. Rheum. Dis. 79:657-665 (2020). (epub ahead of print on Apr. 1, 2020)..

  5. J. Boocock, M. Leask, Y. Okada; Asian Genetic Epidemiology Network (AGEN) Consortium, H. Matsuo, Y. Kawamura, Y. Shi, C. Li, DB. Mount, AK. Mandal, W. Wang, M. Cadzow, Gosling AL, Major TJ, Horsfield JA, Choi HK, Fadason T, O'Sullivan J, Stahl EA, Merriman TR. Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Hum Mol Genet, 923-943 (2020).

  6. A. Akashi, A. Nakayama, Y. Kamatani, T. Higashino, S. Shimizu, Y. Kawamura, M. Imoto, M. Naito, A. Hishida, M. Kawaguchi, M. Takao, M. Matsuo, T. Takada, K. Ichida, H. Ooyama, N. Shinomiya, H. Matsuo, A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. Hum Cell 33, 303-307 (2020).

  7. T. Higashino, K. Morimoto, H. Nakaoka, Y. Toyoda, Y. Kawamura, S. Shimizu, T. Nakamura, K. Hosomichi, A. Nakayama, K. Ooyama, H. Ooyama, T. Shimizu, M. Ueno, T. Ito, T. Tamura, M. Naito, H. Nakashima, M. Kawaguchi, M. Takao, Y. Kawai, N. Osada, K. Ichida, K. Yamamoto, H. Suzuki, N. Shinomiya, I. Inoue, T. Takada, H. Matsuo, Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Ann. Rheum. Dis. 79, 164-166 (2020) (epub ahead of print on Nov 28, 2019.).

  8. Y. Kawamura, H. Nakaoka, A. Nakayama, Y. Okada, K. Yamamoto, T. Higashino, M. Sakiyama, T. Shimizu, H. Ooyama, K. Ooyama, M. Nagase, Y. Hidaka, Y. Shirahama, K. Hosomichi, Y. Nishida, I. Shimoshikiryo, A. Hishida, S. Katsuura-Kamano, S. Shimizu, M. Kawaguchi, H. Uemura, R. Ibusuki, M. Hara, M. Naito, M. Takao, M. Nakajima, S. Iwasawa, H. Nakashima, K. Ohnaka, T. Nakamura, B. Stiburkova, T. R. Merriman, M. Nakatochi, S. Ichihara, M. Yokota, T. Takada, T. Saitoh, Y. Kamatani, A. Takahashi, K. Arisawa, T. Takezaki, K. Tanaka, K. Wakai, M. Kubo, T. Hosoya, K. Ichida, I. Inoue, N. Shinomiya, H. Matsuo. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.Ann. Rheum. Dis, 78, 1430-1437 (2019) (epub ahead of print on Jul. 8, 2019).

  9. M. Nakatochi, M. Kanai, A. Nakayama, A. Hishida, Y. Kawamura, S. Ichihara, M. Akiyama, H. Ikezaki, N. Furusyo, S. Shimizu, K. Yamamoto, M. Hirata, R. Okada, S. Kawai, M. Kawaguchi, Y. Nishida, C. Shimanoe, R. Ibusuki, T. Takezaki, M. Nakajima, M. Takao, E. Ozaki, D. Matsui, T. Nishiyama, S. Suzuki, N. Takashima, Y. Kita, K. Endoh, K. Kuriki, H. Uemura, K. Arisawa, I. Oze, K. Matsuo, Y. Nakamura, H. Mikami, T. Tamura, H. Nakashima, T. Nakamura, N. Kato, K. Matsuda, Y. Murakami, T. Matsubara, M. Naito, M. Kubo, Y. Kamatani, N. Shinomiya, M. Yokota, K. Wakai, Y. Okada, H. Matsuo. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Commun. Biol, 2. 115 (2019).

  10. M. Sakiyama, H. Matsuo, H. Nakaoka, Y. Kawamura, M. Kawaguchi, T. Higashino, A. Nakayama, A. Akashi, J. Ueyama, T. Kondo, K. Wakai, Y. Sakurai, K. Yamamoto, H. Ooyama, N. Shinomiya. Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese. BMC Med Genet, 19(1):96 (2018).

  11. T. Higashino, T. Takada, H. Nakaoka, Y. Toyoda, B. Stiburkova, H. Miyata, Y. Ikebuchi, H. Nakashima, S. Shimizu, M. Kawaguchi, M. Sakiyama, A. Nakayama, A. Akashi, Y. Tanahashi, Y. Kawamura, T. Nakamura, K. Wakai, R. Okada, K. Yamamoto, K. Hosomichi, T. Hosoya, K. Ichida, H. Ooyama, H. Suzuki, I. Inoue, TR. Merriman, N. Shinomiya, H. Matsuo. Multiple common and rare variants of ABCG2 cause gout. RMD Open. 3(2):e000464 (2017).

  12. M. Sakiyama, H. Matsuo, S. Nagamori, W. Ling, Y. Kawamura, A. Nakayama, T. Higashino, T. Chiba, K. Ichida, Y. Kanai, N. Shinomiya. Expression of a human NPT1/SLC17A1 missense variant which increases urate export. Nucleosides Nucleotides Nucleic Acids. 35(10-12):536-542 (2016).

  13. A. Nakayama, H. Nakaoka, K. Yamamoto, M. Sakiyama, A. Shaukat, Y. Toyoda, Y. Okada, Y. Kamatani, T. Nakamura, T. Takada, K. Inoue, T. Yasujima, H. Yuasa, Y. Shirahama, H. Nakashima, S. Shimizu, T. Higashino, Y. Kawamura, H. Ogata, M. Kawaguchi, Y. Ohkawa, I. Danjoh, A. Tokumasu, K. Ooyama, T. Ito, T. Kondo, K. Wakai, B. Stiburkova, K. Pavelka, L. K. Stamp, N. Dalbeth, Eurogout Consortium, Y. Sakurai, H. Suzuki, M. Hosoyamada, S. Fujimori, T. Yokoo, T. Hosoya, I. Inoue, A. Takahashi, M. Kubo, H. Ooyama, T. Shimizu, K. Ichida, N. Shinomiya, T. R. Merriman, H. Matsuo. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Ann Rheum Dis, 76, 869-877 (2017). (epub ahead of print, on Nov 29, 2016).

  14. T. Higashino, H. Matsuo, M. Sakiyama, A. Nakayama, T. Nakamura, T. Takada, H. Ogata, Y. Kawamura, M. Kawaguchi, M. Naito, S. Kawai, Y. Takada, H. Ooyama, H. Suzuki, N. Shinomiya. Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population. Drug Metab Pharmacokinet. 31(6):464-466 2016.

  15. H. Matsuo, K. Yamamoto, H. Nakaoka, A. Nakayama, M. Sakiyama, T. Chiba, A. Takahashi, T. Nakamura, H. Nakashima, Y. Takada, I. Danjoh, S. Shimizu, J. Abe, Y. Kawamura, S. Terashige, H. Ogata, S. Tatsukawa, G. Yin, R. Okada, E. Morita, M. Naito, A. Tokumasu, H. Onoue, K. Iwaya, T. Ito, T. Takada, K. Inoue, Y. Kato, Y. Nakamura, Y. Sakurai, H. Suzuki, Y. Kanai, T. Hosoya, N. Hamajima, I. Inoue, M. Kubo, K. Ichida, H. Ooyama, T. Shimizu, N. Shinomiya, Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis, 75, 652-659 (2016). (epub ahead of print, on Feb 2, 2015).

  16. H. Matsuo, H. Tomiyama, W. Satake, T. Chiba, H. Onoue, Y. Kawamura, A. Nakayama, S. Shimizu, M. Sakiyama, M. Funayama, K. Nishioka, T. Shimizu, K. Kaida, K. Kamakura, T. Toda, N. Hattori, N. Shinomiya, ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout. Ann. Clin. Transl. Neurol, 2, 302-306 (2015).

  17. T. Chiba, H. Matsuo, Y. Kawamura, S. Nagamori, T. Nishiyama, L. Wei, A. Nakayama, T. Nakamura, M. Sakiyama, T. Takada, Y. Taketani, S. Suma, M. Naito, T. Oda, H. Kumagai, Y. Moriyama, K. Ichida, T. Shimizu, Y. Kanai, N. Shinomiya, NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-Function Variant Decreases the Risk of Renal Underexcretion Gout. Arthritis Rheumatol, 67, 281-287 (2015).

  18. A. Nakayama, H. Matsuo, H. Nakaoka, T. Nakamura, H. Nakashima, Y. Takada, Y. Oikawa, T. Takada, M. Sakiyama, S. Shimizu, Y. Kawamura, T. Chiba, J. Abe, K. Wakai, S. Kawai, R. Okada, T. Tamura, Y. Shichijo, A. Akashi, H. Suzuki, T. Hosoya, Y. Sakurai, K. Ichida, N. Shinomiya, Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors. Sci Rep, 4, 5227 (2014).

  19. H. Matsuo, A. Nakayama, M. Sakiyama, T. Chiba, S. Shimizu, Y. Kawamura, H. Nakashima, T. Nakamura, Y. Takada, Y. Oikawa, T. Takada, H. Nakaoka, J. Abe, H. Inoue, K. Wakai, S. Kawai, Y. Guang, H. Nakagawa, T. Ito, K. Niwa, K. Yamamoto, Y. Sakurai, H. Suzuki, T. Hosoya, K. Ichida, T. Shimizu, N. Shinomiya, ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. Sci Rep, 4, 3755 (2014).

  20. T. Chiba, H. Matsuo, S. Nagamori, A. Nakayama, Y. Kawamura, S. Shimizu, M. Sakiyama, M. Hosoyamada, S. Kawai, R. Okada, N. Hamajima, Y. Kanai, N. Shinomiya, Identification of a Hypouricemia Patient with SLC2A9 R380W, A Pathogenic Mutation for Renal Hypouricemia Type 2. Nucleosides Nucleotides Nucleic Acids, 33, 261-265 (2014).

  21. H. Matsuo, K. Ichida, T. Takada, A. Nakayama, H. Nakashima, T. Nakamura, Y. Kawamura, Y. Takada, K. Yamamoto, H. Inoue, Y. Oikawa, M. Naito, A. Hishida, K. Wakai, C. Okada, S. Shimizu, M. Sakiyama, T. Chiba, H. Ogata, K. Niwa, M. Hosoyamada, A. Mori, N. Hamajima, H. Suzuki, Y. Kanai, Y. Sakurai, T. Hosoya, T. Shimizu, N. Shinomiya, Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci Rep 3, 2014 (2013).

  22. K. Ichida, H. Matsuo, T. Takada, A. Nakayama, K. Murakami, T. Shimizu, Y. Yamanashi, H. Kasuga, H. Nakashima, T. Nakamura, Y. Takada, Y. Kawamura, H. Inoue, C. Okada, Y. Utsumi, Y. Ikebuchi, K. Ito, M. Nakamura, Y. Shinohara, M. Hosoyamada, Y. Sakurai, N. Shinomiya, T. Hosoya, H. Suzuki, Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun, 3, 764 (2012).

  23. Y. Kawamura, H. Matsuo, T. Chiba, S. Nagamori, A. Nakayama, H. Inoue, Y. Utsumi, T. Oda, J. Nishiyama, Y. Kanai, N. Shinomiya, Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2). Nucleosides Nucleotides Nucleic Acids, 30, 1105-1111 (2011).

・総説

<痛風・高尿酸血症、低尿酸血症関連>

  1. 河村優輔, 松尾洋孝, 清水聖子, 中山昌喜, 四ノ宮成祥, 【症例で学ぶ!腎泌尿器診療ガイドラインの使い方】(第8章)代謝性疾患 腎性低尿酸血症 モデル症例とピットフォール 腎と透析 88, 377-383 (2020)..

  2. 河村優輔, 石野美咲, 松尾洋孝, 知っておきたいことア・ラ・カルト 腎性低尿酸血症と運動後急性腎障害. Medical Practice 36(1), 158-160 (2019)..

<内分泌・代謝疾患関連>

  1. 河村優輔, 田中祐司, 【プライマリ・ケアでおさえておきたい 重要薬・頻用薬】内分泌疾患薬 甲状腺ホルモン製剤. Medicina 55(4), 350-352 (2018)..