河村優輔の業績一覧 (2022.3.31.更新)

・論文 （*:Equally First Author）

＜痛風・高尿酸血症、低尿酸血症関連＞

  1. Y. Shirai, A. Nakayama, Y. Kawamura (co-first author), Y. Toyoda, M. Nakatochi, S. Shimizu, N. Shinomiya, Y. Okada, H. Matsuo, Coffee consumption reduces gout risk independently of serum uric acid levels: Mendelian randomization analyses across ancestry populations. ACR Open Rheumatol. (2022).

  2. Y. Toyoda, A. Nakayama, M. Nakatochi, Y. Kawamura, H. Nakaoka, K. Yamamoto, S. Shimizu, H. Ooyama, K. Ooyama, T. Shimizu, M. Nagase, Y. Hidaka, K. Ichida, I. Inoue, N. Shinomiya, H. Matsuo, C. Japan Gout Genomics, Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations. Mol Genet Metab. (2022).

  3. S. J. Chang, Y. Toyoda, Y. Kawamura (co-first author), T. Nakamura, M. Nakatochi, A. Nakayama, W. T. Liao, S. Shimizu, T. Takada, K. Takeuchi, K. Wakai, Y. Shi, N. Shinomiya, C. J. Chen, C. Li, Y. Okada, K. Ichida, H. Matsuo, C. for Japan Gout Genomics, A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility. Hum Cell. 35(2):767-770 (2022).
  4. C. Domenighetti, P. E. Sugier, A. Ashok Kumar Sreelatha, C. Schulte, S. Grover, O. Mohamed, B. Portugal, P. May, D. R. Bobbili, M. Radivojkov-Blagojevic, P. Lichtner, A. B. Singleton, D. G. Hernandez, C. Edsall, G. D. Mellick, A. Zimprich, W. Pirker, E. Rogaeva, A. E. Lang, S. Koks, P. Taba, S. Lesage, A. Brice, J. C. Corvol, M. C. Chartier-Harlin, E. Mutez, K. Brockmann, A. B. Deutschlander, G. M. Hadjigeorgiou, E. Dardiotis, L. Stefanis, A. M. Simitsi, E. M. Valente, S. Petrucci, S. Duga, L. Straniero, A. Zecchinelli, G. Pezzoli, L. Brighina, C. Ferrarese, G. Annesi, A. Quattrone, M. Gagliardi, H. Matsuo, Y. Kawamura, N. Hattori, K. Nishioka, S. J. Chung, Y. J. Kim, P. Kolber, B. P. C. van de Warrenburg, B. R. Bloem, J. Aasly, M. Toft, L. Pihlstrom, L. Correia Guedes, J. J. Ferreira, S. Bardien, J. Carr, E. Tolosa, M. Ezquerra, P. Pastor, M. Diez-Fairen, K. Wirdefeldt, N. L. Pedersen, C. Ran, A. C. Belin, A. Puschmann, C. Hellberg, C. E. Clarke, K. E. Morrison, M. Tan, D. Krainc, L. F. Burbulla, M. J. Farrer, R. Kruger, T. Gasser, M. Sharma, A. Elbaz, G. Comprehensive Unbiased Risk Factor Assessment for, C. Environment in Parkinson's Disease, Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. Mov Disord, (2022).
  5. C. Domenighetti, PE. Sugier, AAK. Sreelatha, C. Schulte, S. Grover, O. Mohamed, B. Portugal, P. May, DR. Bobbili, M. Radivojkov-Blagojevic, P. Lichtner, AB. Singleton, DG. Hernandez, C. Edsall, GD. Mellick, A. Zimprich, W. Pirker, E. Rogaeva, AE. Lang, S. Koks, P. Taba, S. Lesage, A. Brice, JC. Corvol, MC. Chartier-Harlin, E. Mutez, K. Brockmann, AB. Deutschländer, GM. Hadjigeorgiou, E. Dardiotis, L. Stefanis, AM. Simits, EM. Valente, S. Petrucci, S. Duga, L. Straniero, A. Zecchinelli, G. Pezzoli, L. Brighina, C. Ferrarese, G. Annesi, A. Quattrone, M. Gagliardi, H. Matsuo, Y. Kawamura, N. Hattori, K. Nishioka, SJ. Chung, YJ. Kim, P. Kolber, BP. van de Warrenburg, BR. Bloem, J. Aasly, M. Toft, L. Pihlstrøm, LC Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, M. Ezquerra, P. Pastor, M. Diez-Fairen, K. Wirdefeldt, NL. Pedersen, C. Ran, AC. Belin, A. Puschmann, C. Hellberg, CE. Clarke, KE. Morrison, M. Tan, D. Krainc, LF. Burbulla, MJ. Farrer, R. Krüger, T. Gasser, M. Sharma, A. Elbaz; Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium. Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease. J Parkinsons Dis. (2021).

  6. Y. Kawamura, A. Nakayama, S. Shimizu, Y. Toyoda, Y. Nishida, A. Hishida, S. Katsuura-Kamano, K. Shibuya, T. Tamura, M. Kawaguchi, S. Suzuki, S. Iwasawa, H. Nakashima, R. Ibusuki, H. Uemura, M. Hara, K. Takeuchi, T. Takada, M. Tsunoda, K. Arisawa, T. Takezaki, K. Tanaka, K. Ichida, K. Wakai, N. Shinomiya, H. Matsuo. A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals. Biomedicines. 9(8):1012, (2021).

  7. A. Nakayama, Y. Kawamura, Y. Toyoda, S. Shimizu, M. Kawaguchi, Y. Aoki, K. Takeuchi, R. Okada, Y. Kubo, T. Imakiire, S. Iwasawa, H. Nakashima, M. Tsunoda, K. Ito, H. Kumagai, T. Takada, K. Ichida, N. Shinomiya, H. Matsuo. Genetic-epidemiological analysis of hypouricemia from 4,993 Japanese on nonfunctional variants of URAT1/SLC22A12 gene. Rheumatology (Oxford). (2021).

  8. M. Sakiyama, H. Matsuo, Y. Toyoda, Y. Yonekura, T. Ishikawa, A. Nakayama, T. Higashino, Y. Kawamura, N. Fujimoto, N. Shinomiya, T. Satoh. Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity. Hum Cell. 34(4):1082-1086, (2021).

  9. Y. Toyoda, Y. Kawamura (co-first author), A. Nakayama, H. Nakaoka, T. Higashino, S. Shimizu, H. Ooyama, K. Morimoto, N. Uchida, R. Shigesawa, K. Takeuchi, I. Inoue, K. Ichida, H. Suzuki, N. Shinomiya, T. Takada, H. Matsuo. Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12. Rheumatology (Oxford). (2021).

  10. M. Nakatochi, Y. Toyoda, M. Kanai, A. Nakayama, Y. Kawamura, A. Hishida, H. Mikami, K. Matsuo, T. Takezaki, Y. Momozawa, Project TBJ, Y. Kamatani, S. Ichihara, N. Shinomiya, M. Yokota, K. Wakai, Y. Okada, H. Matsuo; Japan Uric Acid Genomics Consortium (Japan Urate). An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate. Rheumatology (Oxford). (2021).

  11. M. Ogura, Y. Toyoda, M. Sakiyama, Y. Kawamura, A. Nakayama, Y. Yamanashi, T. Takada, S. Shimizu, T. Higashino, M. Nakajima, M. Naito, A. Hishida, S. Kawai, R. Okada, M. Sasaki, M. Ayaori, H. Suzuki, K. Takata, K. Ikewaki, M. Harada-Shiba, N. Shinomiya, H. Matsuo. Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach. Hum Cell. 34(6):1727-1733, (2021)

  12. M. Kawaguchi, A. Nakayama, Y. Aoyagi, T. Nakamura, S. Shimizu, Y. Kawamura, M. Takao, T. Tamura, A. Hishida, M. Nagayoshi, M. Nagase, K. Ooyama, H. Ooyama, N. Shinomiya, H. Matsuo. Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. Hum Cell. (2021).

  13. Y. Toyoda, T. Takada, H. Miyata, H. Matsuo, H. Kassai, K Nakao, M. Nakatochi, Y. Kawamura, S. Shimizu, N. Shinomiya, K. Ichida, M. Hosoyamada, A. Aiba, H. Suzuki. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Proc Natl Acad Sci U S A. 117(31):18175-18177 (2020).

  14. Y. Kawamura, Y. Toyoda, T. Ohnishi, R. Hisatomi, T. Higashino, A. Nakayama, S. Shimizu, M. Yanagi, I. Kamimaki, R. Fujimaru, H. Suzuki, N. Shinomiya, T. Takada, H. Matsuo. Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families. Rheumatology (Oxford), 59(12):3988-3990 (2020).

  15. A. Nakayama, M. Nakatochi, Y. Kawamura (co-first author), K. Yamamoto, H. Nakaoka, S. Shimizu, T. Higashino, T. Koyama, A. Hishida, K. Kuriki, M. Watanabe, T. Shimizu, K. Ooyama, H. Ooyama, M. Nagase, Y. Hidaka, D. Matsui, T. Tamura, T. Nishiyama, C. Shimanoe, S. Katsuura-Kamano, N. Takashima, Y. Shirai, M. Kawaguchi, M. Takao, R. Sugiyama, Y. Takada, T. Nakamura, H. Nakashima, M. Tsunoda, I. Danjoh, A. Hozawa, K. Hosomichi, Y. Toyoda, Y. Kubota, T. Takada, H. Suzuki, Blanka Stiburkova, T. J. Major, T. R. Merriman, N. Kuriyama, H. Mikami, T. Takezaki, K. Matsuo, S. Suzuki, T. Hosoya, Y. Kamatani, M. Kubo, K. Ichida, K. Wakai, I. Inoue, Y. Okada, N. Shinomiya, H. Matsuo on behalf of Japan Gout Genomics Consortium (Japan Gout). Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. Ann. Rheum. Dis. 79:657-665 (2020). (epub ahead of print on Apr. 1, 2020)..

  16. J. Boocock, M. Leask, Y. Okada; Asian Genetic Epidemiology Network (AGEN) Consortium, H. Matsuo, Y. Kawamura, Y. Shi, C. Li, DB. Mount, AK. Mandal, W. Wang, M. Cadzow, Gosling AL, Major TJ, Horsfield JA, Choi HK, Fadason T, O'Sullivan J, Stahl EA, Merriman TR. Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Hum Mol Genet, 923-943 (2020).

  17. A. Akashi, A. Nakayama, Y. Kamatani, T. Higashino, S. Shimizu, Y. Kawamura, M. Imoto, M. Naito, A. Hishida, M. Kawaguchi, M. Takao, M. Matsuo, T. Takada, K. Ichida, H. Ooyama, N. Shinomiya, H. Matsuo, A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. Hum Cell 33, 303-307 (2020).

  18. T. Higashino, K. Morimoto, H. Nakaoka, Y. Toyoda, Y. Kawamura (co-first author), S. Shimizu, T. Nakamura, K. Hosomichi, A. Nakayama, K. Ooyama, H. Ooyama, T. Shimizu, M. Ueno, T. Ito, T. Tamura, M. Naito, H. Nakashima, M. Kawaguchi, M. Takao, Y. Kawai, N. Osada, K. Ichida, K. Yamamoto, H. Suzuki, N. Shinomiya, I. Inoue, T. Takada, H. Matsuo, Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Ann. Rheum. Dis. 79, 164-166 (2020) (epub ahead of print on Nov 28, 2019.).

  19. Y. Kawamura, H. Nakaoka, A. Nakayama, Y. Okada, K. Yamamoto, T. Higashino, M. Sakiyama, T. Shimizu, H. Ooyama, K. Ooyama, M. Nagase, Y. Hidaka, Y. Shirahama, K. Hosomichi, Y. Nishida, I. Shimoshikiryo, A. Hishida, S. Katsuura-Kamano, S. Shimizu, M. Kawaguchi, H. Uemura, R. Ibusuki, M. Hara, M. Naito, M. Takao, M. Nakajima, S. Iwasawa, H. Nakashima, K. Ohnaka, T. Nakamura, B. Stiburkova, T. R. Merriman, M. Nakatochi, S. Ichihara, M. Yokota, T. Takada, T. Saitoh, Y. Kamatani, A. Takahashi, K. Arisawa, T. Takezaki, K. Tanaka, K. Wakai, M. Kubo, T. Hosoya, K. Ichida, I. Inoue, N. Shinomiya, H. Matsuo. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Ann. Rheum. Dis, 78, 1430-1437 (2019) (epub ahead of print on Jul. 8, 2019).

  20. M. Nakatochi, M. Kanai, A. Nakayama, A. Hishida, Y. Kawamura (co-first author), S. Ichihara, M. Akiyama, H. Ikezaki, N. Furusyo, S. Shimizu, K. Yamamoto, M. Hirata, R. Okada, S. Kawai, M. Kawaguchi, Y. Nishida, C. Shimanoe, R. Ibusuki, T. Takezaki, M. Nakajima, M. Takao, E. Ozaki, D. Matsui, T. Nishiyama, S. Suzuki, N. Takashima, Y. Kita, K. Endoh, K. Kuriki, H. Uemura, K. Arisawa, I. Oze, K. Matsuo, Y. Nakamura, H. Mikami, T. Tamura, H. Nakashima, T. Nakamura, N. Kato, K. Matsuda, Y. Murakami, T. Matsubara, M. Naito, M. Kubo, Y. Kamatani, N. Shinomiya, M. Yokota, K. Wakai, Y. Okada, H. Matsuo. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Commun. Biol, 2. 115 (2019).

  21. M. Sakiyama, H. Matsuo, H. Nakaoka, Y. Kawamura, M. Kawaguchi, T. Higashino, A. Nakayama, A. Akashi, J. Ueyama, T. Kondo, K. Wakai, Y. Sakurai, K. Yamamoto, H. Ooyama, N. Shinomiya. Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese. BMC Med Genet, 19(1):96 (2018).

  22. T. Higashino, T. Takada, H. Nakaoka, Y. Toyoda, B. Stiburkova, H. Miyata, Y. Ikebuchi, H. Nakashima, S. Shimizu, M. Kawaguchi, M. Sakiyama, A. Nakayama, A. Akashi, Y. Tanahashi, Y. Kawamura, T. Nakamura, K. Wakai, R. Okada, K. Yamamoto, K. Hosomichi, T. Hosoya, K. Ichida, H. Ooyama, H. Suzuki, I. Inoue, TR. Merriman, N. Shinomiya, H. Matsuo. Multiple common and rare variants of ABCG2 cause gout. RMD Open. 3(2):e000464 (2017).

  23. M. Sakiyama, H. Matsuo, S. Nagamori, W. Ling, Y. Kawamura, A. Nakayama, T. Higashino, T. Chiba, K. Ichida, Y. Kanai, N. Shinomiya. Expression of a human NPT1/SLC17A1 missense variant which increases urate export. Nucleosides Nucleotides Nucleic Acids. 35(10-12):536-542 (2016).

  24. A. Nakayama, H. Nakaoka, K. Yamamoto, M. Sakiyama, A. Shaukat, Y. Toyoda, Y. Okada, Y. Kamatani, T. Nakamura, T. Takada, K. Inoue, T. Yasujima, H. Yuasa, Y. Shirahama, H. Nakashima, S. Shimizu, T. Higashino, Y. Kawamura, H. Ogata, M. Kawaguchi, Y. Ohkawa, I. Danjoh, A. Tokumasu, K. Ooyama, T. Ito, T. Kondo, K. Wakai, B. Stiburkova, K. Pavelka, L. K. Stamp, N. Dalbeth, Eurogout Consortium, Y. Sakurai, H. Suzuki, M. Hosoyamada, S. Fujimori, T. Yokoo, T. Hosoya, I. Inoue, A. Takahashi, M. Kubo, H. Ooyama, T. Shimizu, K. Ichida, N. Shinomiya, T. R. Merriman, H. Matsuo. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Ann Rheum Dis, 76, 869-877 (2017). (epub ahead of print, on Nov 29, 2016).

  25. T. Higashino, H. Matsuo, M. Sakiyama, A. Nakayama, T. Nakamura, T. Takada, H. Ogata, Y. Kawamura, M. Kawaguchi, M. Naito, S. Kawai, Y. Takada, H. Ooyama, H. Suzuki, N. Shinomiya. Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population. Drug Metab Pharmacokinet. 31(6):464-466 2016.

  26. H. Matsuo, K. Yamamoto, H. Nakaoka, A. Nakayama, M. Sakiyama, T. Chiba, A. Takahashi, T. Nakamura, H. Nakashima, Y. Takada, I. Danjoh, S. Shimizu, J. Abe, Y. Kawamura, S. Terashige, H. Ogata, S. Tatsukawa, G. Yin, R. Okada, E. Morita, M. Naito, A. Tokumasu, H. Onoue, K. Iwaya, T. Ito, T. Takada, K. Inoue, Y. Kato, Y. Nakamura, Y. Sakurai, H. Suzuki, Y. Kanai, T. Hosoya, N. Hamajima, I. Inoue, M. Kubo, K. Ichida, H. Ooyama, T. Shimizu, N. Shinomiya, Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis, 75, 652-659 (2016). (epub ahead of print, on Feb 2, 2015).

  27. H. Matsuo, H. Tomiyama, W. Satake, T. Chiba, H. Onoue, Y. Kawamura, A. Nakayama, S. Shimizu, M. Sakiyama, M. Funayama, K. Nishioka, T. Shimizu, K. Kaida, K. Kamakura, T. Toda, N. Hattori, N. Shinomiya, ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout. Ann. Clin. Transl. Neurol, 2, 302-306 (2015).

  28. T. Chiba, H. Matsuo, Y. Kawamura (co-first author), S. Nagamori, T. Nishiyama, L. Wei, A. Nakayama, T. Nakamura, M. Sakiyama, T. Takada, Y. Taketani, S. Suma, M. Naito, T. Oda, H. Kumagai, Y. Moriyama, K. Ichida, T. Shimizu, Y. Kanai, N. Shinomiya, NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-Function Variant Decreases the Risk of Renal Underexcretion Gout. Arthritis Rheumatol, 67, 281-287 (2015).

  29. A. Nakayama, H. Matsuo, H. Nakaoka, T. Nakamura, H. Nakashima, Y. Takada, Y. Oikawa, T. Takada, M. Sakiyama, S. Shimizu, Y. Kawamura, T. Chiba, J. Abe, K. Wakai, S. Kawai, R. Okada, T. Tamura, Y. Shichijo, A. Akashi, H. Suzuki, T. Hosoya, Y. Sakurai, K. Ichida, N. Shinomiya, Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors. Sci Rep, 4, 5227 (2014).

  30. H. Matsuo, A. Nakayama, M. Sakiyama, T. Chiba, S. Shimizu, Y. Kawamura, H. Nakashima, T. Nakamura, Y. Takada, Y. Oikawa, T. Takada, H. Nakaoka, J. Abe, H. Inoue, K. Wakai, S. Kawai, Y. Guang, H. Nakagawa, T. Ito, K. Niwa, K. Yamamoto, Y. Sakurai, H. Suzuki, T. Hosoya, K. Ichida, T. Shimizu, N. Shinomiya, ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. Sci Rep, 4, 3755 (2014).

  31. T. Chiba, H. Matsuo, S. Nagamori, A. Nakayama, Y. Kawamura, S. Shimizu, M. Sakiyama, M. Hosoyamada, S. Kawai, R. Okada, N. Hamajima, Y. Kanai, N. Shinomiya, Identification of a Hypouricemia Patient with SLC2A9 R380W, A Pathogenic Mutation for Renal Hypouricemia Type 2. Nucleosides Nucleotides Nucleic Acids, 33, 261-265 (2014).

  32. H. Matsuo, K. Ichida, T. Takada, A. Nakayama, H. Nakashima, T. Nakamura, Y. Kawamura, Y. Takada, K. Yamamoto, H. Inoue, Y. Oikawa, M. Naito, A. Hishida, K. Wakai, C. Okada, S. Shimizu, M. Sakiyama, T. Chiba, H. Ogata, K. Niwa, M. Hosoyamada, A. Mori, N. Hamajima, H. Suzuki, Y. Kanai, Y. Sakurai, T. Hosoya, T. Shimizu, N. Shinomiya, Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci Rep 3, 2014 (2013).

  33. K. Ichida, H. Matsuo, T. Takada, A. Nakayama, K. Murakami, T. Shimizu, Y. Yamanashi, H. Kasuga, H. Nakashima, T. Nakamura, Y. Takada, Y. Kawamura, H. Inoue, C. Okada, Y. Utsumi, Y. Ikebuchi, K. Ito, M. Nakamura, Y. Shinohara, M. Hosoyamada, Y. Sakurai, N. Shinomiya, T. Hosoya, H. Suzuki, Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun, 3, 764 (2012).

  34. Y. Kawamura, H. Matsuo, T. Chiba, S. Nagamori, A. Nakayama, H. Inoue, Y. Utsumi, T. Oda, J. Nishiyama, Y. Kanai, N. Shinomiya, Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2). Nucleosides Nucleotides Nucleic Acids, 30, 1105-1111 (2011).

＜総合臨床部・内分泌関連＞

  1. T. Sato, K. Kanda, Y. Kawamura, M. Takeuchi, Sub internal limiting membrane hemorrhage followed by bilateral optic disc hemorrhage in Kikuchi-Fujimoto disease: a case report. BMC Ophthalmol, 21(1), 355 (2021).

・総説

＜痛風・高尿酸血症、低尿酸血症関連＞

  1. 河村優輔, 前原一輝, 桐原真奈, 松尾洋孝. 【生活習慣病の克服に向けたゲノム医療-ゲノム医科学の進展と精密医療の実現】 代謝内分泌疾患 高尿酸血症・痛風のゲノム医科学の進展. 医学のあゆみ 278(5), 390-398, (2021).

  2. 河村優輔, 中山 昌喜, 松尾 洋孝. 【疾患ゲノム研究の最前線】痛風のゲノム研究最前線. BIO Clinica 36(5), 413-418, (2021).

  3. 河村優輔, 松尾洋孝, 清水聖子, 中山昌喜, 四ノ宮成祥. 【症例で学ぶ! 腎泌尿器診療ガイドラインの使い方】 (第8章)代謝性疾患　腎性低尿酸血症　モデル症例とピットフォール 腎と透析 88, 377-383 (2020).

  4. 河村優輔, 石野美咲, 松尾洋孝. 知っておきたいこと ア・ラ・カルト　腎性低尿酸血症と運動後急性腎障害. Medical Practice 36(1), 158-160 (2019).

＜総合臨床部・内分泌関連＞

  1. 佐野あずさ, 河村優輔, 田中祐司. 【病態と薬剤からわかる 水・電解質・酸塩基平衡】（第6章　緊急性の高い病態に伴う電解質異常へのアプローチ）内分泌代謝緊急症. 月刊薬事, (2019).

  2. 河村優輔, 田中祐司. 【プライマリ・ケアでおさえておきたい　重要薬・頻用薬】内分泌疾患薬　甲状腺ホルモン製剤. Medicina 55(4), 350-352 (2018).